Protein / target
DNA polymerase catalytic subunit
Protein at a glance
Biological role
DNA-directed DNA polymerase activity
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication
Subcellular location
Domains and Gene Ontology detail (10)Hide
Gene Ontology
- CDNA polymerase complex
- Chost cell nucleus
- F5'-3' exonuclease activity
- FDNA binding
- FDNA polymerase activity
- FDNA-directed DNA polymerase activity
- Fnucleotide binding
- FRNA-DNA hybrid ribonuclease activity
- Pbidirectional double-stranded viral DNA replication
- PDNA-templated DNA replication
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Immune signalling
- ·host cell nucleus
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Human herpesvirus 1 DNA polymerase inhibitor
Human herpesvirus 1 DNA polymerase inhibitor
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
Show remaining trials (24)Hide
ClinicalTrials.gov via the drug-target graph.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through 2 drugs that target this protein, so each event is news about that drug rather than about the protein directly.
- New publicationCD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
- New publicationKTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma.
- New publicationIbrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia.
- New publicationLong-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
- New publicationEffect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial.
- New publicationAdoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
- New publicationReactive astrocytes protect tissue and preserve function after spinal cord injury.
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.