Protein / target
Leukocyte immunoglobulin-like receptor subfamily B member 1
Protein at a glance
Biological role
HLA-A specific inhibitory MHC class I receptor
Strongest disease association
Epstein-Barr Virus Infections
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Receptor for class I MHC antigens.
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Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251)
Subcellular location
Domains and Gene Ontology detail (58)Hide
Domains & features
Gene Ontology
- Ccytoplasm
- Cexternal side of plasma membrane
- Cextracellular region
- Cplasma membrane
- FHLA-A specific inhibitory MHC class I receptor activity
- FHLA-B specific inhibitory MHC class I receptor activity
- Finhibitory MHC class I receptor activity
- FMHC class I protein binding
- FMHC class I receptor activity
- FMHC class Ib protein binding
- FMHC class Ib protein complex binding
- FMHC class Ib receptor activity
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Immune signalling
- ·adaptive immune response
- ·immune response-inhibiting cell surface receptor signaling pathway
- ·interleukin-10-mediated signaling pathway
- ·negative regulation of alpha-beta T cell activation
Transcriptional regulation
- ·positive regulation of gene expression
- ·positive regulation of transcription by RNA polymerase II
Apoptosis & cell death
- ·negative regulation of dendritic cell apoptotic process
- ·positive regulation of apoptotic process
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene LILRB1
Gene-level evidence surfaced through the gene LILRB1that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (5)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.