Protein / target
Claudin-5
Protein at a glance
Biological role
Structural molecule
Strongest disease association
Genetic Diseases, Inborn
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Plays a major role in tight junction-specific obliteration of the intercellular space
Subcellular location
Domains and Gene Ontology detail (32)Hide
Gene Ontology
- Capicolateral plasma membrane
- Cbicellular tight junction
- Ccell junction
- Ccell-cell junction
- Clateral plasma membrane
- Cmembrane
- Cparanode region of axon
- Cplasma membrane
- CSchmidt-Lanterman incisure
- Ctight junction
- Fidentical protein binding
- Fstructural molecule activity
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Cell proliferation & survival
- ·positive regulation of cell population proliferation
Cell migration
- ·negative regulation of cell migration
Cell adhesion
- ·Plays a major role in tight junction-specific obliteration of the intercellular space
- ·Cell junction, tight junction
- ·bicellular tight junction
- ·cell junction
Transcriptional regulation
- ·negative regulation of gene expression
- ·positive regulation of gene expression
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene CLDN5
Gene-level evidence surfaced through the gene CLDN5 that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
View evidence synthesis (5)Hide
The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Tractability
Antibodies — Emerging
View underlying tractability evidence (3)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.
Related family literature
Papers about “Claudins” — a broader family this protein belongs to. Shown as context; not counted as papers specifically about this protein.
Europe PMC literature, reached through curated HGNC family membership. Membership is a taxonomic relationship — it does not imply this protein participates in every mechanism these papers discuss.