CLDN5

Gene

claudin 5

HGNCHGNC:2047 EnsemblENSG00000184113 NCBI Gene7122

Locus: gene with protein productLocation: 22q11.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Claudin-5O00501

Protein · therapeutic target

Member of “Claudins” · 9 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAWAL · TMVCF · CPETRL1 · BEC1

View full nomenclature history (5)

Previous symbolsAWAL, TMVCF

Alias symbolsCPETRL1, BEC1

Previous namestransmembrane protein deleted in velocardiofacial syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Epilepsy

Neurodevelopmental Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Claudins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.