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Disease

Hypotension

Late-stage therapeutic developmentEmerging research
MeSHHypotension
2
Publications
24
Clinical trials
2021
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones10View all 10
Results posted 2
Results expected 4
Recently completed 4
+2 more in the activity timeline below
Activity timeline10

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Dopamineapproved

Approval — Treatment of hypotension in haemodynamically unstable neonates, infants and children <… (2024)

Clinical trials

17 sponsors · 1 new · 3 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Dopamine vs. Norepinephrine in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure and Systemic Hypotension Due to Pulmonary Hypertension: A Pilot Trial

Phase 4 · Recruiting · University of California, Davis

A Phase 3, Multi-center, Randomized Withdrawal and Long Term Extension Study of Ampreloxetine for the Treatment of Symptomatic Neurogenic Orthostatic Hypotension in Participants With Multiple System Atrophy

Phase 3 · Active, not recruiting · Theravance Biopharma

The Effect of Noradrenaline Infusion Versus Standard Blood Pressure Management on Perioperative HYPotension in NOn-caRdiac Surgery HYP-NOR Trial

Phase 3 · Recruiting · Jagiellonian University

Stent Implantation Versus Medical Therapy for Idiopathic IntracraniaL Hypertension (SIMPLE)

Phase 3 · Recruiting · Beijing Tiantan Hospital

Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor A Randomized, Double-blind, Placebo-controlled, Cross Over Explorative Study

Phase 3 · Recruiting · Vanderbilt University Medical Center

Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia in Neurosurgical Patients

Phase 2/3 · Recruiting · University of Aarhus
Recruiting

Dopamine vs. Norepinephrine in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure and Systemic Hypotension Due to Pulmonary Hypertension: A Pilot Trial

Phase 4 · Recruiting · University of California, Davis

The Effect of Noradrenaline Infusion Versus Standard Blood Pressure Management on Perioperative HYPotension in NOn-caRdiac Surgery HYP-NOR Trial

Phase 3 · Recruiting · Jagiellonian University

Stent Implantation Versus Medical Therapy for Idiopathic IntracraniaL Hypertension (SIMPLE)

Phase 3 · Recruiting · Beijing Tiantan Hospital

Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor A Randomized, Double-blind, Placebo-controlled, Cross Over Explorative Study

Phase 3 · Recruiting · Vanderbilt University Medical Center

Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia in Neurosurgical Patients

Phase 2/3 · Recruiting · University of Aarhus
Recently completed

Does Tranexamic Acid Reduce the Need for Deliberate Hypotensive Anesthesia Within Orthognathic Surgery? A Prospective Study

Phase 4 · Completed · University of Alabama at Birmingham

Comparison of Hemodynamic Effect of Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy: a Randomized Controlled Trial.

Phase 4 · Completed · Cairo University

Comparison of Continuous Norepinephrine and Phenylephrine Infusion for Preventing Hypotension During Low-Dose Spinal Anesthesia in Cesarean Delivery: A Randomized Controlled Trial

Phase 4 · Completed · Tam Anh Research Institute

Determination of the 90% Effective Dose of the Initial Bolus of Norepinephrine in Elective Cesarean Section: An Up-Down Study

Phase 4 · Completed · Pontificia Universidad Catolica de Chile

The Efficacy of Adding Leg Wrapping to Prophylactic Norepinephrine Infusion in Reducing the Incidence of Post-spinal Hypotension in Elective Cesarean Section: A PROSPECTIVE DOUBLE- BLINDED RANDOMIZED CLINICAL TRIAL

Phase 4 · Completed · Fayoum University

Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate (AFF RVR): Comparing Calcium Pre-treatment vs Placebo in Prevention of Diltiazem Induced Hypotension

Phase 4 · Completed · Wake Forest University Health Sciences

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2024emaApproval — Dopamine· Treatment of hypotension in haemodynamically unstable neonates, infants and children < 18 years source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20192021
Leading journals2
  • JAMA1
  • The New England journal of medicine1
Leading researchers8
  • Albert M1
  • Bandeen-Roche K1
  • Bhatt DL1
  • Cannon CP1
  • Coresh J1
  • Gottesman RF1
  • Gross AL1
  • Knopman DS1
Affiliations (unnormalised)6
  • From Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School1
  • George Washington University Milken Institute School of Public Health1
  • Johns Hopkins Bloomberg School of Public Health1
  • Johns Hopkins Center on Aging and Health1
  • Johns Hopkins University School of Medicine1
  • Mayo Clinic1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Identifiers
MeSHHypotension
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.