Protein / target

Penicillin-binding protein 1A

mrcAP02918Escherichia coli (strain K12)Swiss-Prot
UniProt: P02918NCBI Gene: 947907
30
Clinical trials
3
Drugs targeting

Protein at a glance

Biological role

Serine-type D-Ala-D-Ala carboxypeptidase activity

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)

Subcellular location

Cell inner membrane
Domains and Gene Ontology detail (10)

Gene Ontology

  • Couter membrane-bounded periplasmic space
  • Cplasma membrane
  • Fpenicillin binding
  • Fpeptidoglycan glycosyltransferase activity
  • Fserine-type D-Ala-D-Ala carboxypeptidase activity
  • Pcell wall organization
  • Ppeptidoglycan biosynthetic process
  • Pproteolysis
  • Pregulation of cell shape
  • Presponse to antibiotic

850 aa · 94 kDa

Biological roles

What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.

ProteolysisGOMetabolic enzyme activityGO
View supporting evidence

Proteolysis

  • ·serine-type D-Ala-D-Ala carboxypeptidase activity
  • ·proteolysis

Metabolic enzyme activity

  • ·peptidoglycan glycosyltransferase activity

Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.

Drugs targeting this protein

3

Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.

Ampicillin
Inhibitor

Bacterial penicillin-binding protein inhibitor

Acts on a complex — shared with dacB, dacC, ftsI +3 more · 1 of 7 recorded protein targets

Amoxicillin
Inhibitor

Bacterial penicillin-binding protein inhibitor

Acts on a complex — shared with dacB, dacC, ftsI +3 more · 1 of 7 recorded protein targets

Cefiderocol
Inhibitor

Bacterial penicillin-binding protein inhibitor

Acts on a complex — shared with dacB, dacC, ftsI +3 more · 1 of 7 recorded protein targets

ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.

Clinical trials

30

Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.

Comparison of the Efficacy of Tegoprazan-containing Versus Esomeprazole-containing Dual Therapy for Helicobacter Pylori Eradication: a Prospective, Multicenter, Randomized Controlled Study （SHARE2301）NA

UNKNOWN · via Amoxicillin · NCT05870683

Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical TrialPHASE4

UNKNOWN · via Amoxicillin · NCT02735395

A Multicenter, Randomized, Open-Label Comparison of the Safety And Efficacy of Tigecycline With That of Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Complicated Skin And Skin Structure InfectionsPHASE4

COMPLETED · via Ampicillin · NCT00368537

Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles)PHASE3

COMPLETED · via Amoxicillin · NCT02701595

Clinical, Microbiological and Quality of Life Outcomes Following Use of Systemic and Local Antimicrobials in the Management of Odontogenic Infections in Paediatric PatientsPHASE2

COMPLETED · via Amoxicillin · NCT03761264

Functionalization of a Volume-stable Collagen Matrix (VCMX) Using Injectable Platelet Rich Fibrin (i-PRF) for the Treatment of Single Gingival RecessionNA

UNKNOWN · via Amoxicillin · NCT05916742

Show remaining trials (24)
Sequential Helicobacter Pylori Eradication Therapy in Myanmar; a Randomized Clinical Trial of Efficacy and TolerabilityPHASE4

COMPLETED · via Amoxicillin · NCT04132479

Open-label, Multicentre Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Efficacy Of Ceftaroline In Neonates And Young Infants With Late-onset SepsisPHASE2

TERMINATED · via Ampicillin · NCT02424734

Comparison of Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the Third-line Eradication of H. Pylori- a Multicenter Randomized TrialPHASE4

UNKNOWN · via Amoxicillin · NCT03555526

Azithromycin for Severe Acute Malnutrition in CMAM, NigeriaPHASE3

TERMINATED · via Amoxicillin · NCT05473234

Term Prelabour Rupture of Membranes Antibiotic Prophylaxis (PROMab) TrialPHASE4

NOT_YET_RECRUITING · via Ampicillin · NCT07563504

Clinical, Microbiological and Immunological Evaluation of the Effects of Systemic Probiotics in the Periodontal TreatmentPHASE3

UNKNOWN · via Amoxicillin · NCT03733379

Ciprofloxacin, Ampicillin-sulbactam and Placebo Prophylaxis in Laparoscopic Cholecystectomy. A Randomized Controlled StudyPHASE4

TERMINATED · via Ampicillin · NCT01888822

A Phase 3 Randomized Multicenter Study to Evaluate the Efficacy and Safety of Open-Label Dual Therapy With Oral Vonoprazan 20 mg or Double-Blind Triple Therapy With Oral Vonoprazan 20 mg Compared to Double-Blind Triple Therapy With Oral Lansoprazole 30 mg Daily in Patients With Helicobacter Pylori InfectionPHASE3

COMPLETED · via Amoxicillin · NCT04167670

Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Oral Antibiotics in the Community-based Treatment of Severe Acute Malnutrition in Malawian ChildrenNA

COMPLETED · via Amoxicillin · NCT01000298

Evaluation of the Efficacy of an Antibiotic Combined With Standard Treatment in Severe Alcoholic HepatitisPHASE3

COMPLETED · via Amoxicillin · NCT02281929

Susceptibility Changes Among Oral Microorganisms Following Single Dose Antibiotic ProphylaxisPHASE3

COMPLETED · via Amoxicillin · NCT01829529

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)PHASE1

COMPLETED · via Amoxicillin · NCT02707042

Intraluminal Therapy for Helicobacter Pylori InfectionPHASE4

COMPLETED · via Amoxicillin · NCT03124420

Local, Phase IV, Multicenter, Double-blind, Randomized, Parallel, With Two Treatment Arms, Placebo-controlled Study to Evaluate the Reduction of Inflammatory Symptoms in the Treatment of Bacterial Pharyngitis With Ketoprofen and Amoxicillin in Pediatric Patients.PHASE4

TERMINATED · via Amoxicillin · NCT00799838

Clinical Efficacy of Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months Attending Mulago Hospital: A Randomized Clinical Trial.PHASE3

COMPLETED · via Amoxicillin · NCT00933049

TREAT-GNB [CR-GNB]PHASE4

RECRUITING · via Cefiderocol · NCT07004049

Oral Penicillin Challenge in the Pediatric Emergency DepartmentPHASE4

COMPLETED · via Amoxicillin · NCT03404804

Full-mouth Periodontal Debridement Associated With Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical TrialPHASE2/PHASE3

COMPLETED · via Amoxicillin · NCT02969928

Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple TherapyPHASE4

COMPLETED · via Amoxicillin · NCT03609892

A Randomized Controlled Trial Investigating if Antibiotic Use in the First 48 Hours of Life Adversely Impacts the Preterm Infant MicrobiomeNA

COMPLETED · via Ampicillin · NCT02477423

Efficacy of Helicobacter Pylori Eradication on Symptoms of Functional Dyspepsia - A Randomised Controlled TrialNA

COMPLETED · via Amoxicillin · NCT04697641

Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori TreatmentPHASE4

UNKNOWN · via Amoxicillin · NCT03139253

Antibiotic Prophylaxis Prior to the Insertion of Orthodontic Mini-screw Implants: a Randomized Controlled TrialEARLY_PHASE1

COMPLETED · via Amoxicillin · NCT03582605

Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.PyloriPHASE4

COMPLETED · via Amoxicillin · NCT01667575

ClinicalTrials.gov via the drug-target graph.

What's happening now

60

Recent activity around this target, drawn from one canonical event stream. Every item is reached through 3 drugs that target this protein, so each event is news about that drug rather than about the protein directly.

  1. Label change2026-07-17

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050785)

    fda · regulatory · fda · via Amoxicillin

  2. Label change2026-07-17

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050755)

    fda · regulatory · fda · via Amoxicillin

  3. Label change2026-07-17

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050720)

    fda · regulatory · fda · via Amoxicillin

  4. Label change2026-07-17

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050575)

    fda · regulatory · fda · via Amoxicillin

  5. Industry development2026-07-14
    Ozone based advanced oxidation for antibiotic amoxicillin removal from aqueous environment with kinetic and economic evaluation

    Nature — Environmental Sciences · news · via Amoxicillin

  6. Label change2024-12-20

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050785)

    fda · regulatory · fda · via Amoxicillin

  7. Label change2024-12-20

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050755)

    fda · regulatory · fda · via Amoxicillin

  8. Label change2024-05-01

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050785)

    fda · regulatory · fda · via Amoxicillin

  9. Label change2024-05-01

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050755)

    fda · regulatory · fda · via Amoxicillin

  10. Label change2024-05-01

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050720)

    fda · regulatory · fda · via Amoxicillin

  11. Label change2024-05-01

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050575)

    fda · regulatory · fda · via Amoxicillin

  12. Label change2022-11-02

    Label change: AMOXICILLIN AND CLAVULANATE POTASSIUM (NDA050785)

    fda · regulatory · fda · via Amoxicillin

Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.