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Drug

Ampicillin

In clinical development
ClassBacterial penicillin-binding protein inhibitorEmerging researchLate-stage development
Also known as ABPC, AP, Amficot, Ampicillin Trihydrate+18 more

ABPC, AP, Amficot, Ampicillin Trihydrate, Ampicillin acid, Ampicillin-Probenecid, Ampicillin-Sulbactam, Omnipen, Omnipen-N, Polycillin-PRB, Polyflex, Principen, Totacillin-N, Unasyn, Unasyn ADD-Vantage, Aminobenzylpenicillin, D-(-)-ampicillin, Marcillin, Totacillin, Ampicilina, Ampicilline, Ampicillinum.

RxNorm733ChEMBLCHEMBL174ATCJ01CA01ATCJ01CA51ATCS01AA19UNII7C782967RD
2
Research papers
5
Active clinical trials
7
Protein targets
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Cefiderocol and Ampicillin-sulbactam vs. Colistin or Colistin-meropenem for Carbapenem Resistant Acinetobacter Baumannii Bacteremia or Hospital-acquired Pneumonia: Controlled Clinical Study With Historical Controls (CASCADE)

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

A Phase 3 Prospective, Randomized, Multicenter, Active-controlled Study to Evaluate the Efficacy and Safety of BV100 Plus Low-dose Polymyxin B Compared With Colistin Plus High-dose Ampicillin/Sulbactam in the Treatment of Adult Patients With Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia Caused by Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex

Clinical trial2026-05-04Results expected Q4 2027 · ClinicalTrials.gov

Term Prelabour Rupture of Membranes Antibiotic Prophylaxis (PROMab) Trial

Clinical trial2026-05-04Results expected Q1 2027 · ClinicalTrials.gov

Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery

Clinical trial2026-01-29Results expected Q4 2026 · ClinicalTrials.gov

NICU Antibiotics and Outcomes Trial

Clinical trial2026-01-15Completed · ClinicalTrials.gov

Prophylactic Effects of Different Duration of Intravenous Ampicillin for Preventing Surgical Site Infection in Third Molar Surgery: a Randomized Controlled Trial

Clinical trial2025-09-01Completed · ClinicalTrials.gov

The Endourology Disease Group for Excellence (EDGE) Consortium: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Percutaneous Nephrolithotomy in Patients With Moderate Risk of Postoperative Infection

Clinical trial2025-03-01Completed · ClinicalTrials.gov

A Randomized Trial to Investigate Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition in Mulago Hospital, Kampala, Uganda

Clinical trial2024-06-14Primary completion · ClinicalTrials.gov

Supportive Care and Antibiotics for Severe Pneumonia Among Hospitalized Children (SEARCH): A Pragmatic Randomised Controlled Trial

Clinical trial2024-04-05Completed · ClinicalTrials.gov

TREAT: Treatment of ppROM With Erythromycin vs. Azithromycin Trial

Clinical trial2023-12-08Terminated · ClinicalTrials.gov

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.

Research2018-07-20Nature communications

Corticosteroids for pneumonia.

Research2017-12-13The Cochrane database of systematic reviews

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Ampicillin
Aliases & brands
ABPCAPAmficotAmpicillin TrihydrateAmpicillin acidAmpicillin-ProbenecidAmpicillin-SulbactamOmnipenOmnipen-NPolycillin-PRBPolyflexPrincipenTotacillin-NUnasynUnasyn ADD-VantageAminobenzylpenicillinD-(-)-ampicillinMarcillinTotacillinAmpicilinaAmpicillineAmpicillinum
RxNorm CUI
733
ChEMBL ID
CHEMBL174
ATC codes
J01CA01J01CA51S01AA19
UNII
7C782967RD
Primary mechanism
Bacterial penicillin-binding protein inhibitor

Pharmacology & targets

7 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

D-alanyl-D-alanine carboxypeptidase DacB
dacB · P24228
INHIBITORBacterial penicillin-binding protein inhibitor
Peptidoglycan D,D-transpeptidase FtsI
ftsI · P0AD68
INHIBITORBacterial penicillin-binding protein inhibitor
Penicillin-binding protein 1A
mrcA · P02918
INHIBITORBacterial penicillin-binding protein inhibitor
Penicillin-binding protein 1B
mrcB · P02919
INHIBITORBacterial penicillin-binding protein inhibitor
D-alanyl-D-alanine carboxypeptidase DacA
dacA · P0AEB2
INHIBITORBacterial penicillin-binding protein inhibitor
Peptidoglycan D,D-transpeptidase MrdA
mrdA · P0AD65
INHIBITORBacterial penicillin-binding protein inhibitor
D-alanyl-D-alanine carboxypeptidase DacC
dacC · P08506
INHIBITORBacterial penicillin-binding protein inhibitor

Clinical trials

22 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
22
registered trials across all phases
LATEST COMPLETION 2026
5
Active studies
5
Recruiting
20
Late-stage (III+)
11
Completed
6
Discontinued
PHASE DISTRIBUTIONn = 22
Phase 11Phase 21Phase 2 / 31Phase 35Phase 49Phase N / A5

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Term Prelabour Rupture of Membranes Antibiotic Prophylaxis (PROMab) Trial

Not yet recruitingPH IVSarawak General Hospitaln=3202027

Cefiderocol and Ampicillin-sulbactam vs. Colistin or Colistin-meropenem for Carbapenem Resistant Acinetobacter Baumannii Bacteremia or Hospital-acquired Pneumonia: Controlled Clinical Study With Historical Controls (CASCADE)

RecruitingPH IVRambam Health Care Campusn=7342026

NICU Antibiotics and Outcomes Trial

CompletedPH IVMichael Morowitzn=3592026

Prophylactic Effects of Different Duration of Intravenous Ampicillin for Preventing Surgical Site Infection in Third Molar Surgery: a Randomized Controlled Trial

CompletedPH IVUji Takeda Hospitaln=702025

The EDGE Consortium: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Percutaneous Nephrolithotomy: Part 1

CompletedPH IVUniversity of California, San Diegon=862019

Recent completions

Trials that read out recently, adding to the completed evidence base.

NICU Antibiotics and Outcomes Trial

CompletedPH IVMichael Morowitzn=3592026

Prophylactic Effects of Different Duration of Intravenous Ampicillin for Preventing Surgical Site Infection in Third Molar Surgery: a Randomized Controlled Trial

CompletedPH IVUji Takeda Hospitaln=702025

The Endourology Disease Group for Excellence (EDGE) Consortium: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Percutaneous Nephrolithotomy in Patients With Moderate Risk of Postoperative Infection

CompletedN/AUniversity of California, San Diegon=3302025

Supportive Care and Antibiotics for Severe Pneumonia Among Hospitalized Children (SEARCH): A Pragmatic Randomised Controlled Trial

CompletedPH IIIKey trialUniversity of Oxfordn=4,3922024

Different Azithromycin Protocols for Management of Preterm Pre-labor Rupture of Membranes

CompletedN/AAssiut Universityn=3002021

A Randomized Controlled Trial Investigating if Antibiotic Use in the First 48 Hours of Life Adversely Impacts the Preterm Infant Microbiome

CompletedN/AUniversity of Chicagon=272019

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20172018
Most influential

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.

Nature communications · 2018 · 414 cites

Corticosteroids for pneumonia.

The Cochrane database of systematic reviews · 2017 · 157 cites
Recent papers

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.

Nature communications · 2018 · 414 cites

Corticosteroids for pneumonia.

The Cochrane database of systematic reviews · 2017 · 157 cites
Journals, researchers & institutions
Top journals
  • Nature communications1
  • The Cochrane database of systematic reviews1
Leading researchers
  • Avni T1
  • Carrara E1
  • Chaix A1
  • Chang MW1
  • Knight R1
  • Leibovici L1
  • Marotz CA1
  • Panda S1
Leading institutions
free-text, unnormalised
  • Center for Microbiome Innovation1
  • Protein Biology Laboratory1
  • Regulatory Biology Laboratory1
  • The Salk Institute1
  • University of California1

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Amphotericin B

Studied across 3 of the same disease areas as Ampicillin in the shared literature.

3 shared diseases1 shared paper
Insulin

Studied across 3 of the same disease areas as Ampicillin in the shared literature.

3 shared diseases1 shared paper
Metronidazole

Studied across 3 of the same disease areas as Ampicillin in the shared literature.

3 shared diseases1 shared paper
Neomycin

Studied across 3 of the same disease areas as Ampicillin in the shared literature.

3 shared diseases1 shared paper
Vancomycin

Studied across 3 of the same disease areas as Ampicillin in the shared literature.

3 shared diseases1 shared paper
Hydrocortisone

Studied across 2 of the same disease areas as Ampicillin in the shared literature.

2 shared diseases1 shared paper
Budesonide

Studied across the same disease area as Ampicillin in the shared literature.

1 shared disease1 shared paper
Dexamethasone

Studied across the same disease area as Ampicillin in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials