Drug

Neomycin

In clinical development

ClassBacterial 70S ribosome inhibitorEmerging researchLate-stage development

Also known as AK-Neo-Dex, AK-Spore, AK-Spore HC, AK-Trol+69 more

AK-Neo-Dex, AK-Spore, AK-Spore HC, AK-Trol, Antibiotic Ear, Antibiotic-Cort Ear, Campho-Phenique Maximum Strength, Coly Mycin S, Coly-Mycin S, Cort-Biotic, Cortatrigen, Cortatrigen Modified, Cortisporin, Cortisporin-TC, Cuadriderma, Dexacidin, Dexacine, Dexamethasone-Neomycin-Polymyxin B, Dexasporin, Drotic, Ear-Eze, Lanabiotic, Lazersporin-C, Masporin Otic, Maxitrol, Methadex, Mycifradin, Myciguent, Mycitracin Plus Pain Reliever, Mycitracin Triple Antibiotic, Neo-Cortef, Neo-Decadron, Neo-Decadron Cream, Neo-Dex, Neo-Dexair, Neo-Polycin, Neo-Polycin HC, Neo-Predef, Neo-Synalar, Neo-Tab, Neocin PG, Neoptic, Neotricin HC, Neovet, Ocu-Cort, Ocu-Spore-B, Ocu-Spore-G, Ocu-Trol, Ocutricin, Ocutricin HC, Oti-Sone, Otic Care Ear, Otic Ear Care, Otic care, Oticin HC, Otimar, Otocort Sterile Suspension, Pediotic, Poly Pred, Poly-Dex, Septa, Spectrocin Plus, Tresaderm, Tri Biozene, Tribiotic Plus, Cortomycin, Dexamethasone-Neomycin, Neocin, Neomicina, Bacitracin/Neomycin/Polymyxin B Ophthalmic, Hydrocortisone/Neomycin/Polymyxin B, Hydrocortisone/Neomycin/Polymyxin B, Otic, Neomycin Sulfate.

RxNorm7299 ChEMBLCHEMBL3989751 ATCR02AB01 ATCS01AA03 ATCS02AA07 ATCA07AA01 ATCB05CA09 ATCJ01GB05 ATCA07AA51 ATCS03AA01 ATCA01AB08 ATCD06AX04UNIII16QD7X297

Research papers

Active clinical trials

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Pilot Trial of Fecal Microbiota Transplantation and Re-Introduction of Anti-PD-1 Therapy in dMMR Colorectal Adenocarcinoma Anti-PD-1 Non-Responders

Clinical trial2026-06-12Results expected Q4 2027 · ClinicalTrials.gov

An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of Intestinal Microbiota Transplantation In Patients With Chronic Heart Failure

Clinical trial2026-05-05Results expected Q3 2027 · ClinicalTrials.gov

Neomycine/Metronidazole- vs Rifaximin-based Gut Decolonisation Prior to Colon Surgery: a Randomized Multicenter Trial

Clinical trial2025-09-18Results expected Q1 2028 · ClinicalTrials.gov

Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Clinical trial2024-02-06Results posted · ClinicalTrials.gov

Pre-Operative Mechanical Bowel Preparation And Prophylactic Oral Antibiotics For Pediatric Patients Undergoing Elective Colorectal Surgery: A Feasibility Randomized Controlled Trial

Clinical trial2024-01-30Primary completion · ClinicalTrials.gov

Decolonization of Carbapenem-resistant Enterobacterales (CRE) in Patients With Faecal Carriage of CRE With Neomycin

Clinical trial2023-12-31Primary completion · ClinicalTrials.gov

Systems Biology of Inactivated Rabies Vaccine in Healthy Adults With or Without Use of Broad Spectrum Antibiotics

Clinical trial2023-06-08Results posted · ClinicalTrials.gov

An Open-Label Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Clinical trial2022-02-09Results posted · ClinicalTrials.gov

Combined Mechanical and Oral Antibiotic Bowel Preparation Versus Oral Antibiotics Alone for the Reduction of Surgical Site Infection Following Elective Colorectal Resection

Clinical trial2020-10-01Primary completion · ClinicalTrials.gov

Methane Production and Glycemic Regulation in Pre-diabetic Subjects: Role of Methane in Glycemic Control

Clinical trial2019-05-02Results posted · ClinicalTrials.gov

Systems Biology of Inactivated Influenza Vaccine (IIV) in Healthy Adults With or Without Use of Broad Spectrum Antibiotics

Clinical trial2018-08-15Results posted · ClinicalTrials.gov

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.

Research2018-07-20Nature communications

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Neomycin

Aliases & brands

AK-Neo-DexAK-SporeAK-Spore HCAK-TrolAntibiotic EarAntibiotic-Cort EarCampho-Phenique Maximum StrengthColy Mycin SColy-Mycin SCort-BioticCortatrigenCortatrigen ModifiedCortisporinCortisporin-TCCuadridermaDexacidinDexacineDexamethasone-Neomycin-Polymyxin BDexasporinDroticEar-EzeLanabioticLazersporin-CMasporin OticMaxitrolMethadexMycifradinMyciguentMycitracin Plus Pain RelieverMycitracin Triple AntibioticNeo-CortefNeo-DecadronNeo-Decadron CreamNeo-DexNeo-DexairNeo-PolycinNeo-Polycin HCNeo-PredefNeo-SynalarNeo-TabNeocin PGNeopticNeotricin HCNeovetOcu-CortOcu-Spore-BOcu-Spore-GOcu-TrolOcutricinOcutricin HCOti-SoneOtic Care EarOtic Ear CareOtic careOticin HCOtimarOtocort Sterile SuspensionPedioticPoly PredPoly-DexSeptaSpectrocin PlusTresadermTri BiozeneTribiotic PlusCortomycinDexamethasone-NeomycinNeocinNeomicinaBacitracin/Neomycin/Polymyxin B OphthalmicHydrocortisone/Neomycin/Polymyxin BHydrocortisone/Neomycin/Polymyxin B, OticNeomycin Sulfate

RxNorm CUI

7299

ChEMBL ID

CHEMBL3989751

ATC codes

R02AB01S01AA03S02AA07A07AA01B05CA09J01GB05A07AA51S03AA01A01AB08D06AX04

UNII

I16QD7X297

Primary mechanism

Bacterial 70S ribosome inhibitor

Pharmacology & targets

55 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Small ribosomal subunit protein uS2

rpsB · P0A7V0