Protein / target

Large ribosomal subunit protein bL25

rplYP68919Escherichia coli (strain K12)Swiss-Prot
UniProt: P68919NCBI Gene: 93774996
30
Clinical trials
8
Drugs targeting

Protein at a glance

Biological role

Structural constituent of ribosome

Derived from structured UniProt, Open Targets and literature data on this page.

Protein profile

UniProt 2026_02

Canonical identity and biological annotation from UniProt.

Function

This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Binds to the 5S rRNA independently of L5 and L18. Not required for binding of the 5S rRNA/L5/L18 subcomplex to 23S rRNA

Domains and Gene Ontology detail (10)

Gene Ontology

  • Ccytoplasm
  • Ccytosol
  • Ccytosolic large ribosomal subunit
  • F5S rRNA binding
  • Fstructural constituent of ribosome
  • Pcytoplasmic translation
  • Pnegative regulation of translation
  • Presponse to radiation
  • Pribosomal large subunit assembly
  • Ptranslation

94 aa · 11 kDa

Drugs targeting this protein

8

Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.

Azithromycin
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

Doxycycline
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 59 recorded protein targets — broad pharmacology

Neomycin
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

Clarithromycin
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

Erythromycin
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

Sisomicin
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

eravacycline
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

Tetracycline
Inhibitor

Bacterial 70S ribosome inhibitor

Acts on a complex — shared with rpsL, rpsR, rpsD +51 more · 1 of 55 recorded protein targets — broad pharmacology

ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.

Clinical trials

30

Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.

Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death: a Phase III Double-blind Randomized Clinical TrialPHASE3

COMPLETED · via Azithromycin · NCT03199547

Randomized Clinical Trial: Use of Azithromycin to Prevent Lung Damage in Preterm Newborns Under Mechanical VentilationPHASE4

COMPLETED · via Azithromycin · NCT03485703

Autologous Stem Cell Transplant With Pomalidomide (CC-4047®) Maintenance Versus Continuous Clarithromycin/ Pomalidomide / Dexamethasone Salvage Therapy in Relapsed or Refractory Multiple Myeloma: A Phase 2 Open-Label Randomized Study by Tristate ConsortiumPHASE2

COMPLETED · via Clarithromycin · NCT01745588

Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New GuineaPHASE3

COMPLETED · via Azithromycin · NCT01955252

Role of Add-on Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary FibrosisNA

RECRUITING · via Azithromycin · NCT05842681

Daily Doxy: Study of Persons Receiving Daily Doxycycline to Inform Sexually Transmitted Infection Prophylaxis RegimensPHASE4

COMPLETED · via Doxycycline · NCT06545656

Show remaining trials (24)
Efficacy of Adding Azithromycin to Cephalosporin for the Prophylaxis Against Infectious Morbidity Following Cesarean Delivery in High Risk WomenPHASE4

COMPLETED · via Azithromycin · NCT04062175

A Study of Intranasal Live Attenuated Influenza Vaccine Immunogenicity and Associations With the Nasopharyngeal Microbiome Among Children in the Gambia - The NASIMMUNE StudyPHASE4

COMPLETED · via Azithromycin · NCT02972957

Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In NepalPHASE3

COMPLETED · via Azithromycin · NCT02773407

The Value of Antibiotic Treatment of Exacerbations of Hospitalised COPD PatientsPHASE4

COMPLETED · via Doxycycline · NCT00170222

Phase II Clinical Trial of Doxycycline 50 mg or 100 mg Daily for the Prevention of Skin Toxicity in Patients With Metastatic Colorectal Cancer Treated With Anti-EGFR and ChemotherapyPHASE2

COMPLETED · via Doxycycline · NCT03448731

Preterm Premature Rupture of Membranes: Erythromycin Versus Azithromycin a Randomized Trial Comparing Their Efficacy to Prolong Latency (PEACE Trial)PHASE3

WITHDRAWN · via Azithromycin · NCT01556334

Azithromycin and Cefixime Combination Versus Azithromycin Alone for the Out-patient Treatment of Clinically Suspected or Confirmed Uncomplicated Typhoid Fever in South Asia; a Randomised Controlled TrialPHASE4

COMPLETED · via Azithromycin · NCT04349826

A Phase III Double-blind, Randomised, Placebo Controlled Trial of Long Term Therapy on Exacerbation Rate in Patients With Stable COPD Using DoxycyclinePHASE3

COMPLETED · via Doxycycline · NCT02305940

Efficacy and Safety of Azithromycin Compared to the Base Therapeutic Regiment of Hydroxychloroquine in Moderate to Severe COVID-19: A Randomized, Controlled, Double-Blind, Clinical TrialPHASE4

UNKNOWN · via Azithromycin · NCT04359316

Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws)PHASE3

COMPLETED · via Azithromycin · NCT05764876

Treatment Failure and Associated Predictors Following Azithromycin Treatment for Urogenital Chlamydial Infection in Males in Youth Correctional FacilitiesPHASE2

COMPLETED · via Azithromycin · NCT03249935

Nutritional Support for Lactating Women and Azithromycin to Infants to Improve Growth Outcomes in Peri-urban Slums of Karachi, Pakistan - Randomized Controlled TrialNA

COMPLETED · via Azithromycin · NCT03564652

An Open-Label Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's DiseasePHASE2

COMPLETED · via Neomycin · NCT03476317

The Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease - a Randomized, Placebo Controlled, Double Blinded, Multicentre, Clinical TrialPHASE3

COMPLETED · via Clarithromycin · NCT00121550

Azithromycine Pour la Vie Des Enfants au Niger - Implémentation et Recherche: Essai mortalité et résistance (Azithromycin for Child Survival in Niger: Mortality Trial and Resistance Trial)PHASE4

COMPLETED · via Azithromycin · NCT04224987

Antenatal Azithromycin to Prevent Preterm Birth in Pregnant Women With Vaginal Cerclage. A Randomized Controlled TrialPHASE4

COMPLETED · via Azithromycin · NCT04278937

Randomised Evaluation of COVID-19 TherapyPHASE3

RECRUITING · via Azithromycin · NCT04381936

LAKANA , a Cluster-randomized, Double-blinded, Parallel Group, Controlled Trial, Testing the Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Rural Mali.PHASE3

COMPLETED · via Azithromycin · NCT04424511

Relationship Between Gastric Emptying and Glycemic Variability in Type 1 Diabetes MellitusPHASE1

COMPLETED · via Erythromycin · NCT02755064

A Drug-Drug Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Patients With B-Cell MalignanciesPHASE1

COMPLETED · via Clarithromycin · NCT04551963

Intra-articular Doxycycline: A Novel Treatment of Adhesive CapsulitisPHASE4

COMPLETED · via Doxycycline · NCT03479502

Open Study of Clarithromycin for the Treatment of Infections Caused by Nontuberculous Mycobacteria (NTM)PHASE4

COMPLETED · via Clarithromycin · NCT00600769

Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis: A Phase III Randomized Control Trial (Doxy-TB)PHASE3

RECRUITING · via Doxycycline · NCT05473520

A Single Arm, Open-label Exploratory Clinical Trial of Azithromycin in Pulmonary SarcoidosisPHASE2

COMPLETED · via Azithromycin · NCT04020380

ClinicalTrials.gov via the drug-target graph.

What's happening now

31

Recent activity around this target, drawn from one canonical event stream. Every item is reached through 8 drugs that target this protein, so each event is news about that drug rather than about the protein directly.

  1. Industry development2026-07-23
    Fe-doped BiVO4/g-C3N4 heterojunction for efficient tetracycline degradation under low-intensity UV irradiation

    Nature — Environmental Sciences · news · via Tetracycline

  2. Label change2026-06-12

    Label change: DOXYCYCLINE (ANDA204234)

    fda · regulatory · fda · via Doxycycline

  3. Label change2025-04-25

    Label change: DOXYCYCLINE (ANDA204234)

    fda · regulatory · fda · via Doxycycline

  4. Label change2025-04-25

    Label change: DOXYCYCLINE (ANDA204234)

    fda · regulatory · fda · via Doxycycline

  5. Label change2025-03-31

    Label change: DOXYCYCLINE (ANDA207757)

    fda · regulatory · fda · via Doxycycline

  6. New publication2024-09-27
    Impact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children.

    Nature communications · 2024 · 13 citations · Europe PMC · via Erythromycin

  7. New publication2024-01-30
    Guidelines of care for the management of acne vulgaris.

    Journal of the American Academy of Dermatology · 2024 · 236 citations · Europe PMC · via Doxycycline

  8. New publication2021-05-02
    New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

    Molecules (Basel, Switzerland) · 2021 · 302 citations · Europe PMC · via Sisomicin

  9. Safety communication2020-12-17

    Drug Safety Update: Erythromycin: update on known risk of infantile hypertrophic pyloric stenosis

    mhra · safety · mhra · via Erythromycin

  10. Safety communication2020-12-17

    Drug Safety Update: Erythromycin: caution required due to cardiac risks (QT interval prolongation); drug interaction with rivaroxaban

    mhra · safety · mhra · via Erythromycin

  11. New publication2020-09-01
    Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19).

    JAMA cardiology · 2020 · 465 citations · Europe PMC · via Azithromycin

  12. Label change2020-07-08

    Label change: DOXYCYCLINE (ANDA207757)

    fda · regulatory · fda · via Doxycycline

Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.