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Drug

Sisomicin

In clinical development

ClassBacterial 70S ribosome inhibitorEmerging researchLate-stage development

Also known as (2S-CIS)-4-O-(3-AMINO-6-(AMINOMETHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL)-2-DEOXY-6-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-D-STREPTAMINE, 2-DEOXY-4-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-6-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-.ALPHA.-D-GLYCERO-HEX-4-ENOPYRANOSYL)-L-STREPTAMINE, O-3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA-L-ARABINOPYRANOSYL-(1->4)-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-.ALPHA.-D-GLYCERO-HEX-4-ENOPYRANOSYL-(1->6))-2-DEOXY-L-STREPTAMINE.

RxNorm9806 ChEMBLCHEMBL221886 ATCJ01GB08UNIIX55XSL74YQ

1

Research papers

55

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

Research2021-05-02Molecules (Basel, Switzerland)

Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas

Clinical trial2007-09-01Withdrawn · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Sisomicin

Aliases & brands

(2S-CIS)-4-O-(3-AMINO-6-(AMINOMETHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL)-2-DEOXY-6-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-D-STREPTAMINE2-DEOXY-4-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-6-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-.ALPHA.-D-GLYCERO-HEX-4-ENOPYRANOSYL)-L-STREPTAMINEO-3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA-L-ARABINOPYRANOSYL-(1->4)-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-.ALPHA.-D-GLYCERO-HEX-4-ENOPYRANOSYL-(1->6))-2-DEOXY-L-STREPTAMINE

RxNorm CUI

9806

ChEMBL ID

CHEMBL221886

ATC codes

J01GB08

UNII

X55XSL74YQ

Primary mechanism

Bacterial 70S ribosome inhibitor

Pharmacology & targets

55 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Small ribosomal subunit protein uS2

rpsB · P0A7V0

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL4

rplD · P60723

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein bS1

rpsA · P0AG67

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS10

rpsJ · P0A7R5

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS11

rpsK · P0A7R9

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS12

rpsL · P0A7S3

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS13

rpsM · P0A7S9

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS14

rpsN · P0AG59

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS15

rpsO · P0ADZ4

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein bS16

rpsP · P0A7T3

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS17

rpsQ · P0AG63

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein bS18

rpsR · P0A7T7

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS19

rpsS · P0A7U3

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein bS20

rpsT · P0A7U7

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein bS21

rpsU · P68679

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS3

rpsC · P0A7V3

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS4

rpsD · P0A7V8

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS5

rpsE · P0A7W1

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein bS6

rpsF · P02358

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS7

rpsG · P02359

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS8

rpsH · P0A7W7

INHIBITORBacterial 70S ribosome inhibitor

Small ribosomal subunit protein uS9

rpsI · P0A7X3

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL10

rplJ · P0A7J3

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL11

rplK · P0A7J7

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL13

rplM · P0AA10

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL14

rplN · P0ADY3

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL15

rplO · P02413

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL16

rplP · P0ADY7

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL17

rplQ · P0AG44

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL18

rplR · P0C018

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL19

rplS · P0A7K6

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL1

rplA · P0A7L0

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL20

rplT · P0A7L3

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL21

rplU · P0AG48

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL22

rplV · P61175

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL23

rplW · P0ADZ0

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL24

rplX · P60624

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL25

rplY · P68919

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL27

rpmA · P0A7L8

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL28

rpmB · P0A7M2

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL29

rpmC · P0A7M6

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL2

rplB · P60422

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL30

rpmD · P0AG51

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL31B

ykgM · P0A7N1

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL31

rpmE · P0A7M9

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL32

rpmF · P0A7N4

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL33

rpmG · P0A7N9

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL34

rpmH · P0A7P5

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL35

rpmI · P0A7Q1

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL36B

rpmJ2 · Q2EEQ2

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL36A

rpmJ1 · P0A7Q6

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL3

rplC · P60438

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL5

rplE · P62399

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein uL6

rplF · P0AG55

INHIBITORBacterial 70S ribosome inhibitor

Large ribosomal subunit protein bL12

rplL · P0A7K2

INHIBITORBacterial 70S ribosome inhibitor

Clinical trials

1 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

1

registered trials across all phases

1

Late-stage (III+)

1

Discontinued

PHASE DISTRIBUTIONn = 1

Phase 41

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas

WithdrawnPH IVMerck Sharp & Dohme LLC2007

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

Molecules (Basel, Switzerland) · 2021 · 302 cites

Recent papers

New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

Molecules (Basel, Switzerland) · 2021 · 302 cites

Major research themes2

Drug Design1Drug Resistance, Multiple, Bacterial1

Journals, researchers & institutions

Top journals

Molecules (Basel, Switzerland)1

Leading researchers

Pregnolato M1
Taccani M1
Terreni M1

Leading institutions

free-text, unnormalised

University of Pavia1

Related drugs

7 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Acts on the same molecular target as Sisomicin, with 2 overlapping disease areas.

55 shared targets2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Sisomicin in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Sisomicin in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Sisomicin in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Sisomicin in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Sisomicin in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Sisomicin in the shared literature.

2 shared diseases1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials