Protein / target
Large ribosomal subunit protein uL2
Protein at a glance
Biological role
Structural constituent of ribosome
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function
Component of the large ribosomal subunit (PubMed:3298242, PubMed:8722025). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:8722025). One of the primary rRNA binding proteins (PubMed:3298242). Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation (PubMed:8722025). It has been suggested to have peptidyltransferase activity; this is highly controversial (Probable)
Domains and Gene Ontology detail (11)Hide
Gene Ontology
- Ccytoplasm
- Ccytosol
- Ccytosolic large ribosomal subunit
- FRNA binding
- FrRNA binding
- Fstructural constituent of ribosome
- Ftransferase activity
- Fzinc ion binding
- Pcytoplasmic translation
- Pnegative regulation of DNA-templated DNA replication initiation
- Pribosomal large subunit assembly
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
View supporting evidenceHide supporting evidence
Metabolic enzyme activity
- ·Component of the large ribosomal subunit (PubMed:3298242, PubMed:8722025). The ribosome…
- ·transferase activity
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Drugs targeting this protein
Whether each drug engages this protein directly or through a complex, and how many other targets are recorded for it. Direct binders with few recorded targets are listed first.
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
Bacterial 70S ribosome inhibitor
ChEMBL mechanism, action type and target identity. Open Targets clinical status and indications.
Clinical trials
Trials of drugs that target this protein — reached indirectly through those drugs, so a trial listed here studies the drug, not the protein.
Show remaining trials (24)Hide
ClinicalTrials.gov via the drug-target graph.
What's happening now
Recent activity around this target, drawn from one canonical event stream. Every item is reached through 8 drugs that target this protein, so each event is news about that drug rather than about the protein directly.
- Industry developmentFe-doped BiVO4/g-C3N4 heterojunction for efficient tetracycline degradation under low-intensity UV irradiation
- Label change
Label change: DOXYCYCLINE (ANDA204234)
- Label change
Label change: DOXYCYCLINE (ANDA204234)
- Label change
Label change: DOXYCYCLINE (ANDA204234)
- Label change
Label change: DOXYCYCLINE (ANDA207757)
- New publicationImpact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children.
- New publicationGuidelines of care for the management of acne vulgaris.
- New publicationNew Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.
- Safety communication
Drug Safety Update: Erythromycin: update on known risk of infantile hypertrophic pyloric stenosis
- Safety communication
Drug Safety Update: Erythromycin: caution required due to cardiac risks (QT interval prolongation); drug interaction with rivaroxaban
- New publicationRisk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19).
- Label change
Label change: DOXYCYCLINE (ANDA207757)
Objective event titles are shown unmodified; the event kind and significance line are derived from structured fields. Forefront AttentionEvent stream aggregating Europe PMC Regulatory filings ClinicalTrials.gov.