Back to discover
Disease

Disseminated Intravascular Coagulation

Late-stage therapeutic developmentEmerging research
MeSHDisseminated Intravascular Coagulation
2
Publications
10
Clinical trials
5
Related conditions
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Cardiovascular manifestations and treatment considerations in COVID-19.

Research2020-04-30Heart (British Cardiac Society)

COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation.

Research2020-01-01Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones (1 completed or reporting results).
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

8 sponsors · 1 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
10
All trials
0
Active
3
Late-stage
6
Completed
Recently completed

A Single-blind, Placebo Controlled, Dose Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BAY 3389934 Intravenous Infusions in Healthy Japanese Participants.

Phase 1 · Completed · Bayer

Infusional Fluorouracil and Weekly Docetaxel as First-line Therapy for Gastric Cancer With Bone Marrow Metastasis and Disseminated Intravascular Coagulation: a Multi-center, Phase II Trail

Phase 2 · Completed · Sixth Affiliated Hospital, Sun Yat-sen University

Prospective Randomized Versus Placebo Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study

N/A · Completed · University Hospital, Strasbourg, France

A Post-Marketing Clinical Pharmacokinetics Study of ART-123 in DIC Subjects With Renal Impairment

Phase 4 · Completed · Asahi Kasei Therapeutics Corporation

An Open-label Study of KW-3357 Compared to Plasma-derived Antithrombin for Disseminated Intravascular Coagulation (DIC) Associated With Infection

Phase 3 · Completed · Kyowa Kirin Co., Ltd.

A Randomized, Double-Blind, Placebo-Controlled, Phase-2B Study to Assess the Safety and Efficacy Effects of ART-123 on Subjects With Sepsis and Disseminated Intravascular Coagulation

Phase 2 · Completed · Artisan Pharma, Inc.

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Cardiovascular manifestations and treatment considerations in COVID-19.

Heart (British Cardiac Society) · 2020 · 266 cites

COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2020 · 259 cites
Recent publications

Cardiovascular manifestations and treatment considerations in COVID-19.

Heart (British Cardiac Society) · 2020 · 266 cites

COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2020 · 259 cites
Major themes2
  • Betacoronavirus1
  • Pandemics1
Leading journals2
  • Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis1
  • Heart (British Cardiac Society)1
Leading researchers8
  • Chen T1
  • Chen Y1
  • Ferrari V1
  • Han Y1
  • Jagasia D1
  • Kang Y1
  • Makris M1
  • Miesbach W1
Affiliations (unnormalised)5
  • Department of Haemostaseology and Hemophilia Center1
  • Sheffield Haemophilia and Thrombosis Centre1
  • University of Pennsylvania Perelman School of Medicine1
  • University of Sheffield1
  • West China Hospital1

Related conditions

5 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Coronavirus Infections2COVID-192Cytokine Release Syndrome2Pneumonia, Viral2Severe Acute Respiratory Syndrome2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.

Identifiers
MeSHDisseminated Intravascular Coagulation
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.