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Disease

Duodenal ulcer

Late-stage therapeutic development

Also known as curling Ulcer, curling's ulcers, duodenal ulcer (disease), stress Ulcer.

9
Clinical trials
12
Associated genes
7
Related proteins
Current focus
Leptin biologyMyelin basic biologyTherapeutic development

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials with recent milestones (1 completed or reporting results).
Clinical Milestones2View
Results posted 1
Recently completed 1
Activity timeline2

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
9
All trials
1
Active
7
Late-stage
6
Completed
Late-stage studies

An Open Label, Parallel Group, Multi-centre, Phase III Study to Assess the Efficacy and Safety of D961H for the Maintenance Therapy Following Initial Treatment in Japanese Paediatric Patients With Reflux Esophagitis and for the Prevention of Recurrence of Gastric Ulcer or Duodenal Ulcer in Japanese Paediatric Patients Treated With Non-steroidal Anti-inflammatory Drugs or Low-dose Aspirin

Phase 3 · Completed · AstraZeneca

A Multi-center, Randomized, Double-blind, Active-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of LXI-15028 Compared to Lansoprazole in the Treatment of Duodenal Ulcer in Chinese Patients for up to 6 Weeks

Phase 3 · Completed · Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment. - A Multicenter, Randomized, Parallel-group, Open-label Trial-

Phase 2/3 · Completed · Eisai Co., Ltd.

The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers: A Randomized, Parallel-controlled Multi-center Study

Phase 4 · Completed · The Third Xiangya Hospital of Central South University

A Phase 3, Multicenter, Single-blind, AG-1749-controlled, Parallel-group, Long-term Extension Study to Evaluate the Safety and Efficacy of TAK-438 (10 mg or 20 mg, Orally, Once Daily) for the Prevention of Recurrent Gastric or Duodenal Ulcers During Long-term Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)

Phase 3 · Completed · Takeda

A Study to Investigate the Preventive Effect of AG-1749 Against the Recurrence of Gastric and Duodenal Ulcers During Long-term Treatment With Nonsteroid Anti-inflammatory Drug

Phase 3 · Completed · Takeda
Recently completed

An Open Label, Parallel Group, Multi-centre, Phase III Study to Assess the Efficacy and Safety of D961H for the Maintenance Therapy Following Initial Treatment in Japanese Paediatric Patients With Reflux Esophagitis and for the Prevention of Recurrence of Gastric Ulcer or Duodenal Ulcer in Japanese Paediatric Patients Treated With Non-steroidal Anti-inflammatory Drugs or Low-dose Aspirin

Phase 3 · Completed · AstraZeneca

A Multi-center, Randomized, Double-blind, Active-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of LXI-15028 Compared to Lansoprazole in the Treatment of Duodenal Ulcer in Chinese Patients for up to 6 Weeks

Phase 3 · Completed · Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers: A Randomized, Parallel-controlled Multi-center Study

Phase 4 · Completed · The Third Xiangya Hospital of Central South University

Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment. - A Multicenter, Randomized, Parallel-group, Open-label Trial-

Phase 2/3 · Completed · Eisai Co., Ltd.

A Phase 3, Multicenter, Single-blind, AG-1749-controlled, Parallel-group, Long-term Extension Study to Evaluate the Safety and Efficacy of TAK-438 (10 mg or 20 mg, Orally, Once Daily) for the Prevention of Recurrent Gastric or Duodenal Ulcers During Long-term Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)

Phase 3 · Completed · Takeda

A Study to Investigate the Preventive Effect of AG-1749 Against the Recurrence of Gastric and Duodenal Ulcers During Long-term Treatment With Nonsteroid Anti-inflammatory Drug

Phase 3 · Completed · Takeda

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ATP4A0.60HRH20.58ABO0.52PSCA0.49CA60.44PLCL20.40ARC0.38GGT10.38CNDP20.34URAD0.33SLC41A30.33NRTN0.32

Disease biology

7 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Potassium-transporting ATPase alpha chain 1via ATP4A0.60Myelin basic proteinvia MBP0.30Vesicular glutamate transporter 2via SLC17A60.29Leptinvia LEP0.26Gastrin/cholecystokinin type B receptorvia CCKBR0.26Orexin/Hypocretin receptor type 1via HCRTR10.22Galactoside alpha-(1,2)-fucosyltransferase 1via FUT10.13

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A PEPTIC ULCER located in the DUODENUM.

Synonyms

curling Ulcer, curling's ulcers, duodenal ulcer (disease), stress Ulcer

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.