ATP4A

Gene

ATPase H+/K+ transporting subunit alpha

HGNCHGNC:819 EnsemblENSG00000105675 NCBI Gene495

Locus: gene with protein productLocation: 19q13.12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Potassium-transporting ATPase alpha chain 1P20648

Protein · therapeutic target

Clinically validated target · 16 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asATP6A

View full nomenclature history (6)

Alias symbolsATP6A

Previous namesATPase, H+/K+ exchanging, alpha polypeptide, ATPase H+/K+ transporting alpha subunit

Alias namesgastric H,K-ATPase alpha subunit, H(+)-K(+)-ATPase alpha subunit, proton pump

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Gastroesophageal Reflux

Duodenal ulcer

Gastrinoma

Dyspepsia

Arthritis, Rheumatoid

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATPase H+/K+ transporting

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-09-13.

Open TargetsGene–disease associations from the Open Targets Platform.