Headache Disorders
Recent clinical, regulatory, research and industry developments relating to this disease.
Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q3 2027.
- Active recent publication activity.
Research HighlightsViewHide
- 2026-03-01Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.Kollenburg L · 2026
Clinical MilestonesViewHide
- 2026-05-19New Methods for Evaluating Preventive Migraine TreatmentResults expected Q3 2028
- 2026-03-06Cognitive Behavioral Therapy Via Telehealth + Amitriptyline Compared to Cognitive Behavioral Therapy Via Telehealth: Pediatric Migraine Prevention (Responding With Evidence and Access for Childhood Headaches)Results expected Q3 2027
- 2025-12-31A Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic MigrainePrimary completion
- 2026-05-19ClinicalNew Methods for Evaluating Preventive Migraine TreatmentResults expected Q3 2028
- 2026-03-06ClinicalCognitive Behavioral Therapy Via Telehealth + Amitriptyline Compared to Cognitive Behavioral Therapy Via Telehealth: Pediatric Migraine Prevention (Responding With Evidence and Access for Childhood Headaches)Results expected Q3 2027
- 2026-03-01ResearchBridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.Kollenburg L · 2026
- 2025-12-31ClinicalA Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic MigrainePrimary completion
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes4
- Headache Disorders2
- Brain1
- Epilepsy1
- Nerve Net1
Leading journals2
- Brain : a journal of neurology1
- The journal of headache and pain1
Leading researchers8
- Arnts H1
- Ashina S1
- Burstein R1
- Dominguez M1
- Fornari A1
- Grazzi L1
- Guekht A1
- Kollenburg L1
Affiliations (unnormalised)6
- Aarhus University Hospital1
- Australian Institute of Migraine1
- Beth Israel Deaconess Medical Center1
- Canisius Wilhelmina Hospital1
- Chinese PLA General Hospital1
- College of Medicine and Brain Research Center1
Reference
Authoritative identity, definition & identifiers.
Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.