Disease

Hemolysis

Late-stage therapeutic developmentEmerging research

MeSHHemolysis

Publications

Clinical trials

2019

Latest publication

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this disease.

Synthesis and biological characterization of silver nanoparticles derived from the cyanobacterium Oscillatoria limnetica.

Research2019-09-10Scientific reports

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

1 clinical trial expected to report results, the earliest in Q2 2027.

Upcoming Milestones

Q2 2027A Phase 3 Open-Label Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Clinically Significant Extravascular Hemolysis

Major developments

Upcoming trial readoutImportant

A Phase 3 Open-Label Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Clinically Significant Extravascular Hemolysis

Results expected Q2 20272025-12-23

Clinical Milestones1View

Results expected 1

2025-12-23A Phase 3 Open-Label Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Clinically Significant Extravascular HemolysisResults expected Q2 2027

Activity timeline1

2025-12-23ClinicalA Phase 3 Open-Label Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Clinically Significant Extravascular HemolysisResults expected Q2 2027

Clinical trials

6 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

Phase 3 · Recruiting · Alexion Pharmaceuticals, Inc.

HEMolysis in a Percutaneous Axial Flow Left Ventricular Assist Device, Effects of Pentoxifylline in a Randomized Controlled Trial

Phase 4 · Withdrawn · Cedars-Sinai Medical Center

Recruiting

Phase 3 · Recruiting · Alexion Pharmaceuticals, Inc.

Recently completed

The Role of Hemolysis in Promoting Thrombosis During Mechanical Circulatory Support With Continuous Flow Pumps (Aim 2)

Early Phase 1 · Completed · Montefiore Medical Center

An Open Label, Single Arm, Multiple Dose Study to Assess Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of LNP023 When Administered in Addition to Standard of Care (SoC) in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis

Phase 2 · Completed · Novartis Pharmaceuticals

The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell

N/A · Completed · Indonesia University

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Synthesis and biological characterization of silver nanoparticles derived from the cyanobacterium Oscillatoria limnetica.

Scientific reports · 2019 · 229 cites

Recent publications

Synthesis and biological characterization of silver nanoparticles derived from the cyanobacterium Oscillatoria limnetica.

Scientific reports · 2019 · 229 cites

Major themes1

Metal Nanoparticles1

Leading journals1

Scientific reports1

Leading researchers4

Abo-Elmagd RA1
Bawazir SS1
Hamouda RA1
Hussein MH1

Affiliations (unnormalised)3

Genetic Engineering & Research Institute1
Mansoura University1
University of Jeddah1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

Identifiers

MeSHHemolysis

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.