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POLR2E

Gene

RNA polymerase II, I and III subunit E

HGNCHGNC:9192EnsemblENSG00000099817NCBI Gene5434
Locus: gene with protein productLocation: 19p13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRPB5 · RPABC1 · XAP4 · hRPB25 · hsRPB5
View full nomenclature history (8)
Alias symbolsRPB5, RPABC1, XAP4, hRPB25, hsRPB5
Previous namespolymerase (RNA) II (DNA directed) polypeptide E (25kD), RNA polymerase II subunit E
Alias namesDNA directed RNA polymerase II 23 kda polypeptide

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

HIV Infections
Neurodegenerative Diseases
Dengue
Influenza, Human
Hemolysis
Basal cell carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

RNA polymerase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.