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Disease

Musculoskeletal Diseases

Late-stage therapeutic developmentEmerging research
MeSHMusculoskeletal Diseases
2
Publications
19
Clinical trials
12
Associated genes
3
Related proteins
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones4View
Results posted 1
Results expected 1
Recently completed 2
Activity timeline4

Clinical trials

15 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
19
All trials
4
Active
5
Late-stage
6
Completed
Late-stage studies

Multicenter, Randomized, Single-blind, Controlled Clinical Trial to Evaluate the Safety and Efficacy of PRGF-ENDORET® Infiltrations in the Treatment of Low Back Pain.

Phase 4 · Recruiting · Biotechnology Institute IMASD

A Prospective Randomized Comparison of the Effects of Lidocaine and Levobupivacaine on Block Dynamics After a Subparaneural Popliteal Sciatic Nerve Block

Phase 4 · Recruiting · Chinese University of Hong Kong

Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial

Phase 4 · Recruiting · Regionshospitalet Silkeborg

A Phase 3 Extension Study of Ataluren (PTC124) in Patients With Nonsense Mutation Dystrophinopathy

Phase 3 · Terminated · PTC Therapeutics

A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study To Evaluate The EFFIcacy and Safety of TNX-102 SL Tablets Taken Daily At Bedtime In Patients With FibRoMyalgia

Phase 3 · Terminated · Tonix Pharmaceuticals, Inc.
Recently completed

Prospective, Multicentre, Single-arm, Open, Confirmatory Trial to Assess Efficacy and Safety of a Navigation System Providing Personalized Soft Tissue Balance Data in Medially-stabilized Total Knee Arthroplasty

N/A · Completed · Medacta International SA

Minimum Effective Local Anaesthetic Volume of a 1:1 Mixture of 2% Lidocaine With 5ug/ml of Epinephrine and 0.5% Levobupivacaine Required for Ultrasound Guided Selective Trunk Block: A Dose Finding Study

N/A · Completed · Chinese University of Hong Kong

Safety/Efficacy of Intra-articular Administration of Autologous Tolerogenic Dendritic Cells for Treatment of Patients With Rheumatoid Arthritis

Phase 1 · Completed · Russian Academy of Medical Sciences

Coordination Between General Practitioners and Physical Therapists in Primary Health Care for Musculoskeletal Pain: Effect on Sick Leave and Referral to Specialist Care.

N/A · Completed · Norwegian University of Science and Technology

A Phase 1, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of Local Muscle Injections of ACE-083 in Healthy Postmenopausal Women

Phase 1 · Completed · Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA

Quality and Process Improvement Using Nurse-led Patient Pathways in an Orthopedic Hospital

N/A · Completed · Zurich University of Applied Sciences

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20152020
Major themes3
  • Coronavirus Infections1
  • Pandemics1
  • Pneumonia, Viral1
Leading journals2
  • European heart journal1
  • Physical therapy1
Leading researchers8
  • Antunes MJ1
  • Bongiorni MG1
  • Casalta JP1
  • Del Zotti F1
  • Dulgheru R1
  • El Khoury G1
  • Erba PA1
  • Geri T1
Affiliations (unnormalised)4
  • Laboratory of Rehabilitation Technologies1
  • School of Nursing1
  • University of Genoa1
  • University of Genoa.1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

WSCD20.42GFPT10.40SLC25A130.40GSDMC0.40ADGRL30.39HAS10.37BMAL10.36NLRC40.36CLVS10.35DPF30.34ARHGAP200.33UBE2U0.32

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

72 kDa type IV collagenasevia MMP20.31Integrin beta-1via ITGB10.23Pituitary adenylate cyclase-activating polypeptidevia ADCYAP10.21

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.

Identifiers
MeSHMusculoskeletal Diseases
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.