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NLRC4

Gene

NLR family CARD domain containing 4

HGNCHGNC:16412EnsemblENSG00000091106NCBI Gene58484
Locus: gene with protein productLocation: 2p22.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCARD12 · CLAN1 · ipaf · CLANA · CLANB · CLANC · CLAND · CLR2.1 · CLAN
View full nomenclature history (12)
Previous symbolsCARD12
Alias symbolsCLAN1, ipaf, CLANA, CLANB, CLANC, CLAND, CLR2.1, CLAN
Previous namescaspase recruitment domain family, member 12
Alias namesnucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4, NOD-like receptor C4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Musculoskeletal Diseases
Genetic Diseases, Inborn
Alopecia
Dermatitis, Atopic
Infections

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR familyCaspase recruitment domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.