Sarcoma, Ewing
Recent clinical, regulatory, research and industry developments relating to this disease.
Cancer-Associated Fibroblast-Like Tumor Cells Remodel the Ewing Sarcoma Tumor Microenvironment.
Children's Oncology Group's 2023 blueprint for research: Bone tumors.
The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q4 2028.
Clinical MilestonesViewHide
- 2026-04-13ClinicalA Randomized, Open-Label, Phase 2 Study Evaluating Abemaciclib in Combination With Irinotecan and Temozolomide in Participants With Relapsed or Refractory Ewing's SarcomaResults posted
- 2026-02-19ClinicalPhase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory SarcomasResults expected Q4 2028
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes7
- Sarcoma, Ewing4
- Bone Neoplasms2
- Cancer-Associated Fibroblasts1
- Neuroectodermal Tumors, Primitive, Peripheral1
- Osteosarcoma1
- Sarcoma1
- Soft Tissue Neoplasms1
Leading journals4
- Clinical cancer research : an official journal of the American Association for Cancer Research1
- Pathologica1
- Pediatric blood & cancer1
- The New England journal of medicine1
Leading researchers8
- Apfelbaum AA1
- Bellan E1
- Bhise SS1
- Binitie O1
- Davis J1
- Dei Tos AP1
- Deng X1
- DuBois SG1
Affiliations (unnormalised)6
- Azienda Ospedale Università Padova1
- Ben Towne Center for Childhood Cancer Research1
- Children's Hospital of Orange County1
- Children's Hospital of Philadelphia Research Institute1
- Clinical Research Division1
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center1
Disease biology
Key proteins & gene products studied in this disease. Number shows shared papers.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.