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NKX2-2

Gene

NK2 homeobox 2

HGNCHGNC:7835EnsemblENSG00000125820NCBI Gene4821
Locus: gene with protein productLocation: 20p11.22

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNKX2B · NKX2.2
View full nomenclature history (4)
Previous symbolsNKX2B
Alias symbolsNKX2.2
Previous namesNK-2 (Drosophila) homolog B, NK2 transcription factor related, locus 2 (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Skin Diseases
Sarcoma, Ewing
Diabetes Mellitus, Type 2
Genetic Diseases, Inborn
Osteosarcoma
Neoplasms
Hodgkin's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NKL subclass homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.