Drug

Aspartic Acid

In clinical development

Emerging researchLate-stage developmentSteady momentum

Also known as (S)-2-aminobutanedioic acid, (S)-2-aminosuccinic acid, 2-Aminosuccinic acid, Acidum asparticum+6 more

(S)-2-aminobutanedioic acid, (S)-2-aminosuccinic acid, 2-Aminosuccinic acid, Acidum asparticum, Asp, D, L-Asp, L-Asparaginsäure, L-Aspartic Acid, ácido aspártico.

RxNorm1169 ChEMBLCHEMBL274323UNII30KYC7MIAI

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Multicenter, Prospective, Randomized Controlled Clinical Study Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in the Treatment of Adult Newly Diagnosed Early Precursor T-cell Acute Lymphoblastic Leukemia (ETP-ALL)

Clinical trial2026-03-31Primary completion · ClinicalTrials.gov

A Phase I, Open-Label Study of the Relative Bioavailability of Evobrutinib Tablet Manufacturing Batches in Healthy Participants

Clinical trial2025-12-23Results posted · ClinicalTrials.gov

A PHASE 1, RANDOMIZED, OPEN-LABEL, 4-PERIOD, CROSSOVER, SINGLE-DOSE STUDY IN HEALTHY PARTICIPANTS TO ESTIMATE THE EFFECT OF TABLET FORMULATION ON THE RELATIVE BIOAVAILABILITY OF MEVROMETOSTAT (PF-06821497)

Clinical trial2025-09-09Withdrawn · ClinicalTrials.gov

A Phase 1 Randomized, Double-Blind Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Bioavailability of NSI-8226 in Healthy Participants

Clinical trial2024-10-29Completed · ClinicalTrials.gov

P-glypoprotein Inhibition Effect on the Pharmacokinetics of Two Tacrolimus Formulations: Prolonged and Extended-release

Clinical trial2023-05-16Completed · ClinicalTrials.gov

Dexmedetomidine Versus Fentanyl on Time to Extubation in Patients With Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy: A Randamized Controlled Trial

Clinical trial2023-05-15Completed · ClinicalTrials.gov

A Bioequivalence Study of HR20031 Tablet in Healthy Subjects

Clinical trial2023-04-04Completed · ClinicalTrials.gov

A Randomized, Open-label, Multiple-dose, 2x3 Crossover Clinical Trial to Investigate the Pharmacokinetic Drug Interaction of JW0201 and C2103 or C2104 After Oral Administration in Healthy Adults

Clinical trial2022-03-23Completed · ClinicalTrials.gov

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Research2020-11-19Cell

Myelination of the nervous system: mechanisms and functions.

Research2014-01-01Annual review of cell and developmental biology

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.

Research2004-09-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Cerebral hypoxia: some new approaches and unanswered questions.

Research1990-08-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Aspartic Acid

Aliases & brands

(S)-2-aminobutanedioic acid(S)-2-aminosuccinic acid2-Aminosuccinic acidAcidum asparticumAspDL-AspL-AsparaginsäureL-Aspartic Acidácido aspártico

RxNorm CUI

1169

ChEMBL ID

CHEMBL274323

UNII

30KYC7MIAI

Clinical trials

32 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2024

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 32

Phase 124Phase 21Phase 33Phase 43Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Study to Assess Current Standard Malaria Treatment Guidelines and Evaluate Recently Developed G6PD Diagnostic Tools in the Republic of the Sudan

CompletedPH IVMenzies School of Health Researchn=3202016

The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability

CompletedPH IVYonsei Universityn=662013

Treatment of High Risk Adult Acute Lymphoblastic Leukemia

CompletedPH IVPETHEMA Foundationn=1002012

RecruitingPH IIIFirst Affiliated Hospital of Zhejiang Universityn=812027

Prevention and Treatment for COVID -19 Associated Severe Pneumonia in The Gambia: a Single-Blinded Randomised Clinical Trial (PaTS-COVID)

Unknown statusPH IIIKey trialLondon School of Hygiene and Tropical Medicinen=1,2002022

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Phase 1 Randomized, Double-Blind Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Bioavailability of NSI-8226 in Healthy Participants

CompletedPH IUniquity One (UNI)n=482024

P-glypoprotein Inhibition Effect on the Pharmacokinetics of Two Tacrolimus Formulations: Prolonged and Extended-release

CompletedPH IIRennes University Hospitaln=272023

Dexmedetomidine Versus Fentanyl on Time to Extubation in Patients With Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy: A Randamized Controlled Trial

CompletedN/AHelwan Universityn=642023

A Bioequivalence Study of HR20031 Tablet in Healthy Subjects

CompletedPH IShandong Suncadia Medicine Co., Ltd.n=962023

A Phase I, Open-Label Study of the Relative Bioavailability of Evobrutinib Tablet Manufacturing Batches in Healthy Participants

CompletedPH IMerck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germanyn=282023

A Randomized, Open-label, Multiple-dose, 2x3 Crossover Clinical Trial to Investigate the Pharmacokinetic Drug Interaction of JW0201 and C2103 or C2104 After Oral Administration in Healthy Adults

CompletedPH IJW Pharmaceuticaln=402022

Research activity

4 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

19902021

Most influential

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Cell · 2021 · 866 cites

Myelination of the nervous system: mechanisms and functions.

Annual review of cell and developmental biology · 2014 · 731 cites

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004 · 539 cites

Cerebral hypoxia: some new approaches and unanswered questions.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1990 · 449 cites

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Glycine

Studied across the same disease area as Aspartic Acid in the shared literature.

1 shared disease1 shared paper

Ifenprodil

Frequently co-studied with Aspartic Acid in the research literature.

1 shared paper

Picrotoxin

Frequently co-studied with Aspartic Acid in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials