Estradiol
Approved · FDAAlso known as 17 Beta-Estradiol, 17-beta estradiol, 17Beta-estradiol, 17beta oestradiol+63 more
17 Beta-Estradiol, 17-beta estradiol, 17Beta-estradiol, 17beta oestradiol, Alora, Bijuva, CLIMARA, Climara Pro, Climaval, Combipatch, Compudose, Delatestadiol, Delestrogen, Dep Androgyn, Depo-Estradiol, Depo-Testadiol, Depotestogen, Divigel, Dotti, Duo-Cyp, Dura-Dumone, Duratestrin, E2 - estradiol, ESTRADIOL 17-BETA, Elestrin, Elleste Solo, Esclim, Estra-Testrin, Estrace, Estraderm, Estradiol Benzoate, Estradiol Cypionate, Estradiol Hemihydrate, Estradiol Vaginal Insert, Estradiol Valerate, Estradiol-17beta, Estrasorb, Estring, Estrogel, Evamist, Fempatch, Femring, Femtrace, Gynodiol, Imvexxy, Lunelle, Lyllana, Menostar, Minivelle, Myfembree, OESTROGEL, Oestradiol, Oestradiol Implants, PROGYNOVA, Prefest, Revalor, Synovex, Synovex C, Synovex H, Synovex S, Vagifem, Vivelle, Yuvafem, Zumenon, beta-Estradiol, cis-Estradiol, Estradiolum.
Recent clinical, regulatory, research and industry developments relating to this drug.
Sorption and desorption of 17α−ethinylestradiol (EE2) and β−estradiol (E2) to nylon microparticles
Label change: ESTRADIOL (ANDA075182)
Label change: ESTRADIOL (ANDA075182)
Label change: ESTRADIOL (ANDA075182)
Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal Women
The association between sex hormones and bone mineral density in US females.
Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations.
Sex hormones differently regulate lipid metabolism genes in primary human hepatocytes.
TFEB controls syncytiotrophoblast formation and hormone production in placenta.
Profile
Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.
Pharmacology & targets
Known molecular targets and mechanisms supported by curated pharmacology databases.
Regulatory timeline
The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.
Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).
Clinical trials
The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.
Late-stage studies
Phase III+ trials still open or recently active — where late-stage evidence is being generated.
Impact of Estradiol on Endothelial Function in Peri-Menopausal Women
Recent completions
Trials that read out recently, adding to the completed evidence base.
Research activity
Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.
Major research themes8
Journals, researchers & institutions
- The Journal of neuroscience : the official journal of the Society for Neuroscience4
- The New England journal of medicine2
- Annals of internal medicine1
- BMC endocrine disorders1
- Cell death and differentiation1
- Clinical journal of the American Society of Nephrology : CJASN1
- McEwen BS3
- Woolley CS3
- Gould E2
- Adams RJ1
- Ahmed A1
- André F1
- Antonio L1
- Balk SP1
- Baylor College of Medicine3
- Laboratory of Neuroendocrinology3
- School of Medicine2
- Aarhus University Hospital1
- Adelaide Institute for Sleep Health1
- Amsterdam University Medical Centers1
Related diseases
Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.
Related drugs
Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).
Studied across 13 of the same disease areas as Estradiol in the shared literature.
Acts on the same molecular target as Estradiol, with 2 overlapping disease areas.
Studied across 6 of the same disease areas as Estradiol in the shared literature.
Studied across 7 of the same disease areas as Estradiol in the shared literature.
Studied across 6 of the same disease areas as Estradiol in the shared literature.
Studied across 6 of the same disease areas as Estradiol in the shared literature.
Studied across 3 of the same disease areas as Estradiol in the shared literature.
Studied across 3 of the same disease areas as Estradiol in the shared literature.
- RxNorm (U.S. National Library of Medicine) — drug identity
- ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
- Europe PMC — research literature
- ClinicalTrials.gov — clinical trials
- Regulatory event sources are credited in the Regulatory Timeline above.