Kynurenine
In clinical developmentAlso known as (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 3-Anthraniloyl-L-alanine, L-kynurenine.
Recent clinical, regulatory, research and industry developments relating to this drug.
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
The Influence of Kynurenine Metabolites on Neurodegenerative Pathologies.
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis.
Tryptophan Metabolism and Gut-Brain Homeostasis.
The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers
Profile
Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.
Clinical trials
The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.
Recent completions
Trials that read out recently, adding to the completed evidence base.
Research activity
Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.
Major research themes8
Journals, researchers & institutions
- International journal of molecular sciences6
- Nature communications2
- British journal of cancer1
- Cell communication and signaling : CCS1
- Cells1
- Cellular & molecular immunology1
- Vécsei L3
- Tanaka M2
- Zhang L2
- Andreasson KI1
- Ay YA1
- Beach TG1
- Belladonna ML1
- Bianchi R1
- Interdisciplinary Excellence Centre2
- University of Szeged2
- Albert Szent-Györgyi Clinical Center1
- Beijing Chest Hospital1
- Center for Cancer Immunotherapy and Immunobiology1
- Center for Global Health1
Related diseases
Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.
Related drugs
Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).
Studied across 5 of the same disease areas as Kynurenine in the shared literature.
Studied across 4 of the same disease areas as Kynurenine in the shared literature.
- RxNorm (U.S. National Library of Medicine) — drug identity
- ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
- Europe PMC — research literature
- ClinicalTrials.gov — clinical trials