Drug

Prednisolone

In clinical development

ClassGlucocorticoid receptor agonistEmerging researchLate-stage developmentCooling momentum

Also known as AK-Cide, AK-Pred, AsmalPred Plus, Blephamide+60 more

AK-Cide, AK-Pred, AsmalPred Plus, Blephamide, Bubbli-Pred, Cetapred, Cortamine, Cotolone, Deltahydrocortisone, Depo-Predate, Econopred, Econopred Plus, Flo-Pred, Hydeltra-T.B.A., Hydeltrasol, Hydroretrocortine, Inflamase Forte, Inflamase Mild, Key-Pred, Key-Pred SP, MILLIPRED, Medasulf, Medicort, Metacortandralone, Metimyd, Ocu-Pred, Ocu-Pred Forte, Ocu-Pred-A, Omnipred, Orapred, PRDL, Pediapred, Poly Pred, Pred Forte, Pred Mild, Pred-G, Pred-Ject-50, Predacort 50, Predaject-50, Predalone 50, Predate-50, Predcor, Predicort RP, Predicort-50, Prednisol, Prednistab, Prelone, Pri-Cortin 50, Sulster, Supred, Surolan, Temaril-P, Vasocidin, Veripred, delta(1)-Dehydrocortisol, delta(1)-Dehydrohydrocortisone, delta(1)-Hydrocortisone, delta-dehydrocortisol, delta-dehydrohydrocortisone, delta-hydrocortisone, Prednisolona, PrednisoLONE Acetate, PrednisoLONE Sodium Phosphate, Prednisolonum.

RxNorm8638 ChEMBLCHEMBL131 ATCS02BA03 ATCD07XA02 ATCR01AD02 ATCA01AC04 ATCD07AA03 ATCR01AD52 ATCC05AA04 ATCS03BA02 ATCA07EA01 ATCH02AB06 ATCA01AC54 ATCS01BA04 ATCS01CB02UNII9PHQ9Y1OLM

Research papers

Active clinical trials

Glucocorticoid receptor

Primary target

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Randomized, Open-label, Multicenter, Phase 2 Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)

Clinical trial2026-07-30Results expected Q4 2027 · ClinicalTrials.gov

Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages, PREMI Trial

Clinical trial2026-07-29Primary completion · ClinicalTrials.gov

A Phase 2 Study of SNDX-5613 in Combination With Chemotherapy for Patients With Relapsed or Refractory KMT2A-Rearranged Infant Leukemia

Clinical trial2026-07-16Results expected Q4 2027 · ClinicalTrials.gov

A Randomized, Open-Label, Multicenter, Phase 3 Study of Zilovertamab Vedotin (MK-2140) in Combination With R-CHP Versus R-CHOP in Participants With Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL) (waveLINE-010)

Clinical trial2026-07-16Results expected Q3 2029 · ClinicalTrials.gov

A Phase 2, Open-label, Multi-cohort Study to Assess the Efficacy and Safety of ASP5541 in Participants With Advanced Prostate Cancer

Clinical trial2026-07-15Results expected Q2 2032 · ClinicalTrials.gov

A Phase 2/3 Randomized, Open-label Study of MK-1045 in Combination With Rituximab in Participants With 1L Follicular Lymphoma

Clinical trial2026-07-10Results expected Q3 2032 · ClinicalTrials.gov

A Multi-centre, Randomised, Placebo-controlled, Double-blind, Parallel-group Trial to Evaluate Safety and Efficacy of Spesolimab (BI 655130) in Adult Patients With Ulcerative Pyoderma Gangrenosum (PG) Who Require Systemic Therapy

Clinical trial2026-07-09Results expected Q4 2027 · ClinicalTrials.gov

A Phase 2 Study of Blinatumomab in Combination With Chemotherapy for Infants With Newly Diagnosed Acute Lymphoblastic Leukemia With Randomization of KMT2A-Rearranged Patients to Addition of Venetoclax

Clinical trial2026-07-09Results expected Q4 2028 · ClinicalTrials.gov

Development of prediction models to select older RA patients with comorbidities for treatment with chronic low-dose glucocorticoids.

Research2023-05-01Rheumatology (Oxford, England)

Cost-effectiveness and cost-utility of add-on, low-dose prednisolone in patients with rheumatoid arthritis aged 65+: The pragmatic, multicenter, placebo-controlled GLORIA trial.

Research2022-10-21Seminars in arthritis and rheumatism

Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial.

Research2022-05-31Annals of the rheumatic diseases

Hepatotoxicity following administration of onasemnogene abeparvovec (AVXS-101) for the treatment of spinal muscular atrophy.

Research2020-11-10Journal of hepatology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Prednisolone

Aliases & brands

AK-CideAK-PredAsmalPred PlusBlephamideBubbli-PredCetapredCortamineCotoloneDeltahydrocortisoneDepo-PredateEconopredEconopred PlusFlo-PredHydeltra-T.B.A.HydeltrasolHydroretrocortineInflamase ForteInflamase MildKey-PredKey-Pred SPMILLIPREDMedasulfMedicortMetacortandraloneMetimydOcu-PredOcu-Pred ForteOcu-Pred-AOmnipredOrapredPRDLPediapredPoly PredPred FortePred MildPred-GPred-Ject-50Predacort 50Predaject-50Predalone 50Predate-50PredcorPredicort RPPredicort-50PrednisolPrednistabPrelonePri-Cortin 50SulsterSupredSurolanTemaril-PVasocidinVeripreddelta(1)-Dehydrocortisoldelta(1)-Dehydrohydrocortisonedelta(1)-Hydrocortisonedelta-dehydrocortisoldelta-dehydrohydrocortisonedelta-hydrocortisonePrednisolonaPrednisoLONE AcetatePrednisoLONE Sodium PhosphatePrednisolonum

RxNorm CUI

8638

ChEMBL ID

CHEMBL131

ATC codes

S02BA03D07XA02R01AD02A01AC04D07AA03R01AD52C05AA04S03BA02A07EA01H02AB06A01AC54S01BA04S01CB02

UNII

9PHQ9Y1OLM

Primary mechanism

Glucocorticoid receptor agonist

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Glucocorticoid receptor

NR3C1 · P04150

AGONISTGlucocorticoid receptor agonist

Clinical trials

194 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

194

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

126

Late-stage (III+)

108

Completed

Discontinued

PHASE DISTRIBUTIONn = 194

Early Phase 12Phase 111Phase 1 / 29Phase 246Phase 2 / 312Phase 347Phase 443Phase N / A24

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Very Low Dose, add-on Prednisolone in Patients With Newly Diagnosed Rheumatoid Arthritis: a Randomised Placebo-controlled Study

Not yet recruitingPH IVChinese University of Hong Kongn=1122028

Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis.

Not yet recruitingPH IVSeoul National University Hospitaln=2062027

Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages, PREMI Trial

RecruitingPH IVLeiden University Medical Centern=4902027

Research on the Treatment of Severe Community-acquired Pneumonia in Children

Unknown statusPH IVBaoping XUn=1602025

Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus: A Randomized Controlled Trial

CompletedPH IVAll India Institute of Medical Sciences, Bhubaneswarn=642025

Recent completions

Trials that read out recently, adding to the completed evidence base.

The Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on the Success of IAN Block and Post Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

CompletedN/ACairo Universityn=1242026

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia

CompletedPH IIIUltragenyx Pharmaceutical Incn=492026

Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus: A Randomized Controlled Trial

CompletedPH IVAll India Institute of Medical Sciences, Bhubaneswarn=642025

A Trial of Prednisolone in Combination With SPI-62 or Placebo in Subjects With Polymyalgia Rheumatica (PMR)

CompletedPH IISparrow Pharmaceuticalsn=662025

Comparison of Outcome Between Dexamethasone Versus Prednisolone Administration in Acute Exacerbation of Childhood Asthma

CompletedN/AMuhammad Aamir Latifn=2242025

Early Administration of Steroids in the Ambulance Setting: An Observational Design Trial

CompletedPH IVUniversity of Floridan=8342024

Research activity

8 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20142023

Most influential

Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer.

The New England journal of medicine · 2017 · 1,563 cites

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.

The New England journal of medicine · 2017 · 1,272 cites

Hepatotoxicity following administration of onasemnogene abeparvovec (AVXS-101) for the treatment of spinal muscular atrophy.

Journal of hepatology · 2021 · 230 cites

Corticosteroids for pneumonia.

The Cochrane database of systematic reviews · 2017 · 157 cites

Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial.

Annals of the rheumatic diseases · 2022 · 108 cites

Randomized comparison of topical prednisolone acetate 1% versus fluorometholone 0.1% in the first year after descemet membrane endothelial keratoplasty.

Cornea · 2014 · 70 cites

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas

Neoplasm Metastasis2 Prostatic Neoplasms2

Related drugs

7 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Budesonide

Acts on the same molecular target as Prednisolone, with an overlapping disease area.

Shared target1 shared disease1 shared paper

Dexamethasone

Acts on the same molecular target as Prednisolone, with an overlapping disease area.

Shared target1 shared disease1 shared paper

Hydrocortisone

Acts on the same molecular target as Prednisolone, with an overlapping disease area.

Shared target1 shared disease1 shared paper

Abiraterone Acetate

Studied across 3 of the same disease areas as Prednisolone in the shared literature.

3 shared diseases2 shared papers

Bilirubin

Studied across 2 of the same disease areas as Prednisolone in the shared literature.

2 shared diseases1 shared paper

Onasemnogene abeparvovec

Studied across 2 of the same disease areas as Prednisolone in the shared literature.

2 shared diseases1 shared paper

Ampicillin

Studied across the same disease area as Prednisolone in the shared literature.

1 shared disease1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials