Back to discover
Drug

Salicylic Acid

In clinical development
Emerging researchLate-stage development
Also known as 2-Carboxyphenol, 2-Hydroxybenzoic acid, AZO Urinary Tract Defense, Acidum salicylicum+119 more

2-Carboxyphenol, 2-Hydroxybenzoic acid, AZO Urinary Tract Defense, Acidum salicylicum, AcneWorx, Acneclir, Acnevir, Akurza, Ala Seb, Ala Seb T, Aliclen, Bensal, Broda Acne Spa, Clear Away, Clear Proof Acne Medication, Clearskin Blemish, Clearskin Pore Penetrating Black Mineral Mask, Clearskin Professional Daily Correcting, Clenziderm, Compound W, Compound W brand of salicylic acid, Cornstick, Cystex, DHS Salicylic Acid 3%, Denorex Extra Strength Reformulated Aug 2012, DermalZone, Dermoneen, Differin Acne Clearing, Dream Pure BB, Duofilm, Duoplant, Durasal, Emersal, Everclean, Exoderm, Fostex Bar, Freezone, Gets-It Corn and Callus Remover, Glycylic, Gordofilm, Hydrisalic, Inova 8-2, Ionil Plus, Keralyt, Keralyt 5, Kleer Plex, MG217 Psoriasis Salicylic Acid, Mediplast, Meted, Mosco Corn & Callus Remover, Mosco Corn and Callus Remover, Mosco One Step Corn Remover, Mosco-Cain, Nizoral Psoriasis, Noxzema Clean, O-carboxyphenol, O-hydroxybenzoic acid, Occlusal-HP, Off-Eazy, Oxy Deep Pore, P & S, P and S, Panscol, Pazol XS, Pernox Scrub Cleanser, Phisoderm Clear Confidence Body Wash, Phisoderm Clear Confidence Daily Gel Face Wash, Propa P.H., Propa P.H. Acne Mask, Psoriasin Wash, RayaSal, Rogaine Anti-Dandruff, SLT, Sal-Plant Gel, Salac, Salactic Film, Salacyn, Salex, Salinocaine, Salitop, Salkera, Salvax, Salycim, Salyntra, Sastid Soap, Scalpicin Scalp Relief, Sebasorb, Sebex, Sebobalance, Sebucare, Sebulex, Sebutone, Selsun Blue Naturals, Skinmedica Purifying Foaming Wash, St. Ives Blemish & Blackhead Control, Stri-Dex, Stri-Dex Clear Gel, Stridex, Super Spot Remover, Tarsum, Thera-Sal, Tussirex, UltraSal-ER, Ultrasal, Verruguin, Verrustat, Versiclear, Virasal, WARTICIDE, Wart Away, Wart-Off Treatment, Wartstick, X-Seb, X-Seb Plus, X-Seb T Pearl, Xalix, Zapzyt Acne Wash, Zit Stick, clear days ahead, ácido salicílico, Inova 8/2, Propa P.H. Skin Cleanser Normal/Sensitive, Sodium Salicylate.

RxNorm9525ChEMBLCHEMBL424ATCS01BC08ATCD01AE12UNIIO414PZ4LPZ
1
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Evaluation of the Efficacy & Safety of Topical Ivermectin Alone or in Combination With Microneedling as Novel Therapeutic Options for Cutaneous Non-genital Warts Versus Topical Salicylic Acid ؛ Randomized Controlled Clinical Trial.

Clinical trial2026-02-09Results expected Q1 2027 · ClinicalTrials.gov

Guidelines of care for the management of acne vulgaris.

Research2024-01-30Journal of the American Academy of Dermatology

Multicentric, Parallel, Randomized, Double Blind Study Under Dermatological Control to Evaluate the Anti-acne Efficacy of a Dermo-cosmetic Product (Fla 688977 33) Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer (Hydréane légère, Cosmétique Active International) During a 12-week Application Period in Male and Female Subjects Presenting With Mild to Moderate Acne

Clinical trial2020-02-17Completed · ClinicalTrials.gov

Randomized, Single Blind, Placebo Controlled Clinical Trial to See the Effect of Combination of Neem, Propylene Glycol and Salicylic Acid in the Treatment of Arsenical Palmar Keratosis

Clinical trial2015-09-01Completed · ClinicalTrials.gov

Comparison of 70% Pyruvic Acid Solution and Duofilm Solution in Treatment of Plantar Wart

Clinical trial2014-09-01Primary completion · ClinicalTrials.gov

Effects of Leaf Extract of Azadirachta Indica in Palmer Arsenical Keratosis: Randomized, Double Blind, Placebo-controlled Trial

Clinical trial2014-03-01Completed · ClinicalTrials.gov

A Single-centre Randomised, Active-controlled, Observer-blinded, Parallel Group Trial to Evaluate the Efficacy and Safety of a Topical Dimeticone Formulation (Loion®) Compared to 10% Salicylic Acid in the Removal of Scaling in Patients With Chronic Psoriasis Capitis

Clinical trial2014-01-01Completed · ClinicalTrials.gov

A Phase I Study of Salicylate for Adult Patients With Advanced Myelodysplastic Disorders or Acute Myelogenous Leukemia

Clinical trial2013-01-18Completed · ClinicalTrials.gov

Topical Clindamycin Salicylic Acid Preparation for the Treatment of Acne Vulgaris

Clinical trial2006-01-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Salicylic Acid
Aliases & brands
2-Carboxyphenol2-Hydroxybenzoic acidAZO Urinary Tract DefenseAcidum salicylicumAcneWorxAcneclirAcnevirAkurzaAla SebAla Seb TAliclenBensalBroda Acne SpaClear AwayClear Proof Acne MedicationClearskin BlemishClearskin Pore Penetrating Black Mineral MaskClearskin Professional Daily CorrectingClenzidermCompound WCompound W brand of salicylic acidCornstickCystexDHS Salicylic Acid 3%Denorex Extra Strength Reformulated Aug 2012DermalZoneDermoneenDifferin Acne ClearingDream Pure BBDuofilmDuoplantDurasalEmersalEvercleanExodermFostex BarFreezoneGets-It Corn and Callus RemoverGlycylicGordofilmHydrisalicInova 8-2Ionil PlusKeralytKeralyt 5Kleer PlexMG217 Psoriasis Salicylic AcidMediplastMetedMosco Corn & Callus RemoverMosco Corn and Callus RemoverMosco One Step Corn RemoverMosco-CainNizoral PsoriasisNoxzema CleanO-carboxyphenolO-hydroxybenzoic acidOcclusal-HPOff-EazyOxy Deep PoreP & SP and SPanscolPazol XSPernox Scrub CleanserPhisoderm Clear Confidence Body WashPhisoderm Clear Confidence Daily Gel Face WashPropa P.H.Propa P.H. Acne MaskPsoriasin WashRayaSalRogaine Anti-DandruffSLTSal-Plant GelSalacSalactic FilmSalacynSalexSalinocaineSalitopSalkeraSalvaxSalycimSalyntraSastid SoapScalpicin Scalp ReliefSebasorbSebexSebobalanceSebucareSebulexSebutoneSelsun Blue NaturalsSkinmedica Purifying Foaming WashSt. Ives Blemish & Blackhead ControlStri-DexStri-Dex Clear GelStridexSuper Spot RemoverTarsumThera-SalTussirexUltraSal-ERUltrasalVerruguinVerrustatVersiclearVirasalWARTICIDEWart AwayWart-Off TreatmentWartstickX-SebX-Seb PlusX-Seb T PearlXalixZapzyt Acne WashZit Stickclear days aheadácido salicílicoInova 8/2Propa P.H. Skin Cleanser Normal/SensitiveSodium Salicylate
RxNorm CUI
9525
ChEMBL ID
CHEMBL424
ATC codes
S01BC08D01AE12
UNII
O414PZ4LPZ

Clinical trials

8 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
8
registered trials across all phases
LATEST COMPLETION 2020
1
Active studies
1
Recruiting
3
Late-stage (III+)
6
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 8
Early Phase 11Phase 11Phase 1 / 21Phase 22Phase 2 / 31Phase 41Phase N / A1

Recent completions

Trials that read out recently, adding to the completed evidence base.

Multicentric, Parallel, Randomized, Double Blind Study Under Dermatological Control to Evaluate the Anti-acne Efficacy of a Dermo-cosmetic Product (Fla 688977 33) Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer (Hydréane légère, Cosmétique Active International) During a 12-week Application Period in Male and Female Subjects Presenting With Mild to Moderate Acne

CompletedPH IVVichy Laboratoiresn=2002020

Randomized, Single Blind, Placebo Controlled Clinical Trial to See the Effect of Combination of Neem, Propylene Glycol and Salicylic Acid in the Treatment of Arsenical Palmar Keratosis

CompletedPH IIBangabandhu Sheikh Mujib Medical University, Dhaka, Bangladeshn=302015

Effects of Leaf Extract of Azadirachta Indica in Palmer Arsenical Keratosis: Randomized, Double Blind, Placebo-controlled Trial

CompletedN/ABangabandhu Sheikh Mujib Medical University, Dhaka, Bangladeshn=502014

A Single-centre Randomised, Active-controlled, Observer-blinded, Parallel Group Trial to Evaluate the Efficacy and Safety of a Topical Dimeticone Formulation (Loion®) Compared to 10% Salicylic Acid in the Removal of Scaling in Patients With Chronic Psoriasis Capitis

CompletedPH IIG. Pohl-Boskamp GmbH & Co. KGn=902014

Topical Clindamycin Salicylic Acid Preparation for the Treatment of Acne Vulgaris

CompletedPH I/IIHadassah Medical Organizationn=402006

A Phase I Study of Salicylate for Adult Patients With Advanced Myelodysplastic Disorders or Acute Myelogenous Leukemia

CompletedPH IMemorial Sloan Kettering Cancer Center2004

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Guidelines of care for the management of acne vulgaris.

Journal of the American Academy of Dermatology · 2024 · 236 cites
Recent papers

Guidelines of care for the management of acne vulgaris.

Journal of the American Academy of Dermatology · 2024 · 236 cites
Major research themes8
Acne Vulgaris1Anti-Bacterial Agents1Benzoyl Peroxide1Dermatologic Agents1Dicarboxylic Acids1Doxycycline1Isotretinoin1Salicylic Acid1
Journals, researchers & institutions
Top journals
  • Journal of the American Academy of Dermatology1
Leading researchers
  • Barbieri JS1
  • Cheng CE1
  • Cook-Bolden F1
  • Desai SR1
  • Druby KM1
  • Freeman EE1
  • Han JM1
  • Keri JE1
Leading institutions
free-text, unnormalised
  • American Academy of Dermatology1
  • Beth Israel Deaconess Medical Center1
  • Brigham and Women's Hospital1
  • Emory University School of Medicine1
  • Massachusetts General Hospital1
  • Mayo Clinic1

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Azelaic acid

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Benzoyl Peroxide

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Clascoterone

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Doxycycline

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Isotretinoin

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Minocycline

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Sarecycline

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
Spironolactone

Studied across the same disease area as Salicylic Acid in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials