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Drug

Scopolamine

In clinical development
ClassMuscarinic acetylcholine receptor M1 antagonistEmerging researchLate-stage developmentRising momentum
Also known as (-)-hyoscine, 6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate, Antispas, Barbidonna+33 more

(-)-hyoscine, 6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate, Antispas, Barbidonna, Barophen, Bellalphen, Bellatal, Chardonna-2, Colidrops, D-Tal, Donnaphen, Donnapine, Donnatal, Elixiral, Haponal, Hyoscine, Hyosophen, Hypersed, Isopto Hyoscine, Malatal, Maldemar, Murocoll 2, Phenobel, Phenohytro, Scopace, Servira, Spasmolin, Spasquid, Spastolate, Transderm Scop, Transderm-Scop, alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester, scopine (-)-tropate, (-)-scopolamine, (1S,3S,5R,6R,7S)-6,7-Epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 6,7-Epoxytropine tropate, Scopolamine Hydrobromide.

RxNorm9601ChEMBLCHEMBL569713ATCS01FA02ATCA04AD01ATCA04AD51ATCN05CM05UNIIDL48G20X8X
3
Research papers
3
Active clinical trials
CHRM1
Primary target
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Representation of Spatiotemporal Information in Human Episodic Memory and Navigation

Clinical trial2026-04-30Results expected Q1 2030 · ClinicalTrials.gov

Behavioral and Pharmacological Manipulation of Time Cell Activity in the Human Mesial Temporal Lobe

Clinical trial2025-10-03Results expected Q4 2026 · ClinicalTrials.gov

A Trial to Evaluate Target Occupancy of Scopolamine at the Muscarinic M1 Receptor

Clinical trial2025-07-01Withdrawn · ClinicalTrials.gov

Toward a Computationally-Informed, Personalized Treatment for Hallucinations

Clinical trial2025-06-05Results expected Q3 2032 · ClinicalTrials.gov

National, Multicenter, Randomized, Double-blind, Triple-dummy, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Escócia Association in the Treatment of Acute Pain

Clinical trial2025-06-01Withdrawn · ClinicalTrials.gov

Nebulizer Delivery of Intranasal Scopolamine

Clinical trial2025-05-07Completed · ClinicalTrials.gov

A Randomised Double-Blinded Placebo-Controlled Trial to Assess the Efficacy and Safety of Scopolamine Compared to Placebo in Individuals With Bipolar Disorder Who Are Experiencing a Depressive Episode

Clinical trial2025-04-29Results posted · ClinicalTrials.gov

Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice.

Research2023-07-20Scientific reports

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety, Efficacy and Pharmacokinetics of DPI-386 Nasal Gel for the Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects With Open-Label Follow-Up

Clinical trial2020-11-23Completed · ClinicalTrials.gov

Open-label, Dose-escalating, Non-randomized, Single-Center Study to Determine the Safety and Pharmacokinetic Profiles of Scopolamine in Healthy Volunteers

Clinical trial2020-05-01Primary completion · ClinicalTrials.gov

Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism.

Research1994-12-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Long-term synaptic depression in the striatum: physiological and pharmacological characterization.

Research1992-11-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Scopolamine
Aliases & brands
(-)-hyoscine6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropateAntispasBarbidonnaBarophenBellalphenBellatalChardonna-2ColidropsD-TalDonnaphenDonnapineDonnatalElixiralHaponalHyoscineHyosophenHypersedIsopto HyoscineMalatalMaldemarMurocoll 2PhenobelPhenohytroScopaceServiraSpasmolinSpasquidSpastolateTransderm ScopTransderm-Scopalpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl esterscopine (-)-tropate(-)-scopolamine(1S,3S,5R,6R,7S)-6,7-Epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate6,7-Epoxytropine tropateScopolamine Hydrobromide
RxNorm CUI
9601
ChEMBL ID
CHEMBL569713
ATC codes
S01FA02A04AD01A04AD51N05CM05
UNII
DL48G20X8X
Primary mechanism
Muscarinic acetylcholine receptor M1 antagonist

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Muscarinic acetylcholine receptor M1
CHRM1 · P11229
ANTAGONISTMuscarinic acetylcholine receptor M1 antagonist

Clinical trials

34 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
34
registered trials across all phases
LATEST COMPLETION 2025
3
Active studies
3
Recruiting
16
Late-stage (III+)
18
Completed
13
Discontinued
PHASE DISTRIBUTIONn = 34
Early Phase 13Phase 18Phase 1 / 21Phase 26Phase 2 / 32Phase 32Phase 43Phase N / A9

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Double-blind, Controlled, Randomized Study Comparing Escitalopram Combined With Scopolamine or Escitalopram in Patients With Major Depressive Disorder

CompletedPH IVCapital Medical Universityn=662018

Absolute Bioavailability/Pharmacokinetic and Residual Drug Analysis of the Transderm Scōp System in Healthy Adults

CompletedPH IVUniversity of Iowan=262018

The Effects of Preoperative Scopolamine Patch Application on the Postoperative Nausea and Vomiting in Microvascular Decompression Surgery

Unknown statusPH IVSeoul National University Hospitaln=602017

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of the Safety and Efficacy of Defender Pharmaceuticals Inc, (DPI)-386 Nasal Gel on Ocean-Going Vessels for the Prevention and Treatment of Nausea Associated With Motion Sickness

Unknown statusPH IIINaval Aeromedical Research Unit, Daytonn=3202021

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety, Efficacy and Pharmacokinetics of DPI-386 Nasal Gel for the Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects With Open-Label Follow-Up

CompletedPH IIIRepurposed Therapeutics, Inc.n=982020

Recent completions

Trials that read out recently, adding to the completed evidence base.

Nebulizer Delivery of Intranasal Scopolamine

CompletedPH IDartmouth-Hitchcock Medical Centern=142025

A Randomised Double-Blinded Placebo-Controlled Trial to Assess the Efficacy and Safety of Scopolamine Compared to Placebo in Individuals With Bipolar Disorder Who Are Experiencing a Depressive Episode

CompletedPH IIDr. Brian Hallahann=552024

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety, Efficacy and Pharmacokinetics of DPI-386 Nasal Gel for the Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects With Open-Label Follow-Up

CompletedPH IIIRepurposed Therapeutics, Inc.n=982020

A Double-blind, Controlled, Randomized Study Comparing Escitalopram Combined With Scopolamine or Escitalopram in Patients With Major Depressive Disorder

CompletedPH IVCapital Medical Universityn=662018

Absolute Bioavailability/Pharmacokinetic and Residual Drug Analysis of the Transderm Scōp System in Healthy Adults

CompletedPH IVUniversity of Iowan=262018

A Feasibility Study of Glycopyrrolate in Comparison to Hyoscine Hydrobromide and Placebo in the Treatment of Hypersalivation Induced by Clozapine

CompletedPH I/IIMersey Care NHS Trustn=292018

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19922023
Most influential

Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1994 · 491 cites

Long-term synaptic depression in the striatum: physiological and pharmacological characterization.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1992 · 491 cites

Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice.

Scientific reports · 2023 · 6 cites
Recent papers

Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice.

Scientific reports · 2023 · 6 cites

Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1994 · 491 cites

Long-term synaptic depression in the striatum: physiological and pharmacological characterization.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1992 · 491 cites
Major research themes2
Paeonia1Scopolamine1
Journals, researchers & institutions
Top journals
  • The Journal of neuroscience : the official journal of the Society for Neuroscience2
  • Scientific reports1
Leading researchers
  • Bernardi G1
  • Calabresi P1
  • Choi CW1
  • Han YE1
  • Kim JH1
  • Kim MS1
  • Kwon O1
  • Lee B1
Leading institutions
free-text, unnormalised
  • Biocenter1
  • Brain Science Institute1
  • Clinica Neurologica1
  • KIST School1
  • Laboratory of Neuroendocrinology1
  • Pukyong National University1

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Alanine

Frequently co-studied with Scopolamine in the research literature.

1 shared paper
Dopamine

Frequently co-studied with Scopolamine in the research literature.

1 shared paper
Estradiol

Frequently co-studied with Scopolamine in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials