ABCB1

Gene

ATP binding cassette subfamily B member 1

HGNCHGNC:40 EnsemblENSG00000085563 NCBI Gene5243

Locus: gene with protein productLocation: 7q21.12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

ATP-dependent translocase ABCB1P08183

Protein · therapeutic target

Clinical-stage target · 5 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCLCS · MDR1 · P-gp · CD243 · GP170 · ABC20 · p-170 · PGY1

View full nomenclature history (12)

Previous symbolsCLCS, MDR1

Alias symbolsP-gp, CD243, GP170, ABC20, p-170, PGY1

Previous namescolchicin sensitivity, ATP-binding cassette, sub-family B (MDR/TAP), member 1

Alias namesmultidrug resistance protein 1, P-glycoprotein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute

Inflammatory Bowel Diseases

Epilepsy

Carcinoma, Non-Small-Cell Lung

Hypertension, Portal

Multiple Myeloma

Myelodysplastic syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesATP binding cassette subfamily BATPase phospholipid transporting

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-09-16.

Open TargetsGene–disease associations from the Open Targets Platform.