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ARHGEF3

Gene

Rho guanine nucleotide exchange factor 3

HGNCHGNC:683EnsemblENSG00000163947NCBI Gene50650
Locus: gene with protein productLocation: 3p14.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSTA3 · XPLN · GEF3 · DKFZP434F2429
View full nomenclature history (7)
Alias symbolsSTA3, XPLN, GEF3, DKFZP434F2429
Previous namesRho guanine nucleotide exchange factor (GEF) 3
Alias namesexchange factor found in platelets and leukemic and neuronal tissues, XPLN, RhoGEF protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Thrombocytopenia 4
Hemorrhagic disease
Glaucoma, Open-Angle
Glaucoma
Cholelithiasis
Thrombophilia
Celiac Disease
Gastritis, Atrophic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Dbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.