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ARHGEF4

Gene

Rho guanine nucleotide exchange factor 4

HGNCHGNC:684EnsemblENSG00000136002NCBI Gene50649
Locus: gene with protein productLocation: 2q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSTM6 · KIAA1112 · ASEF · ASEF1
View full nomenclature history (7)
Alias symbolsSTM6, KIAA1112, ASEF, ASEF1
Previous namesRho guanine nucleotide exchange factor (GEF) 4
Alias namesAPC-stimulated guanine nucleotide exchange factor, APC-stimulated guanine nucleotide exchange factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hematologic Diseases
Liver Diseases
Alcohol drinking
Stroke

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.