BGLAP

Gene

bone gamma-carboxyglutamate protein

HGNCHGNC:1043 EnsemblENSG00000242252 NCBI Gene632

Locus: gene with protein productLocation: 1q22

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

OsteocalcinP02818

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asOCN · BGP

View full nomenclature history (6)

Alias symbolsOCN, BGP

Previous namesbone gamma-carboxyglutamate (gla) protein

Alias namesgamma-carboxyglutamic acid-containing protein, osteocalcin, bone gla protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Renal Insufficiency

Thyroid gland carcinoma

Carcinoma, Renal Cell

Ischemic Stroke

Diabetes Mellitus, Type 2

Diabetes Mellitus

Stroke

Cerebral Hemorrhage

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Gla domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-06-27.

Open TargetsGene–disease associations from the Open Targets Platform.