CASP10

Gene

caspase 10

HGNCHGNC:1500 EnsemblENSG00000003400 NCBI Gene843

Locus: gene with protein productLocation: 2q33.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMCH4 · FLICE-2

View full nomenclature history (5)

Alias symbolsMCH4, FLICE-2

Previous namescaspase 10, apoptosis-related cysteine protease, caspase 10, apoptosis-related cysteine peptidase

Alias namesFAS-associated death domain protein interleukin-1B-converting enzyme 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphoma

Lymphoma, Non-Hodgkin's

Leukemia, Lymphocytic, Chronic, B-Cell

Arthritis, Rheumatoid

Alcohol drinking

Stroke

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CaspasesDeath effector domain containingDeath inducing signaling complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.