CASP9

Gene

caspase 9

HGNCHGNC:1511 EnsemblENSG00000132906 NCBI Gene842

Locus: gene with protein productLocation: 1p36.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Caspase-9P55211

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMCH6 · ICE-LAP6 · APAF-3 · PPP1R56

View full nomenclature history (7)

Alias symbolsMCH6, ICE-LAP6, APAF-3, PPP1R56

Previous namescaspase 9, apoptosis-related cysteine protease, caspase 9, apoptosis-related cysteine peptidase

Alias namesprotein phosphatase 1, regulatory subunit 56

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Gout

Carcinoma, Non-Small-Cell Lung

Breast Neoplasms

Carcinoma, Hepatocellular

Prostate carcinoma

Leukemia, Myeloid, Acute

Lung carcinoma

Gastric carcinoma

Esophageal Squamous Cell Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CaspasesProtein phosphatase 1 regulatory subunitsCaspase recruitment domain containingApoptosome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.