CD40

Gene

CD40 molecule

HGNCHGNC:11919 EnsemblENSG00000101017 NCBI Gene958

Locus: gene with protein productLocation: 20q13.12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor receptor superfamily member 5P25942

Protein · therapeutic target

Clinical-stage target · 10 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTNFRSF5 · p50 · Bp50

View full nomenclature history (5)

Previous symbolsTNFRSF5

Alias symbolsp50, Bp50

Previous namestumor necrosis factor receptor superfamily, member 5, CD40 molecule, TNF receptor superfamily member 5

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Graves' Disease

Inflammatory Bowel Diseases

Crohn's Disease

Multiple Sclerosis

Bipolar Disorder

Mucocutaneous Lymph Node Syndrome

Thyrotoxicosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesTumor necrosis factor receptor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.