CHUK

Gene

component of inhibitor of nuclear factor kappa B kinase complex

HGNCHGNC:1974 EnsemblENSG00000213341 NCBI Gene1147

Locus: gene with protein productLocation: 10q24.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Inhibitor of nuclear factor kappa-B kinase subunit alphaO15111

Protein · therapeutic target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTCF16 · IKK1 · IKK-alpha · IkBKA · NFKBIKA · IKKA

View full nomenclature history (9)

Previous symbolsTCF16

Alias symbolsIKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA

Previous namesconserved helix-loop-helix ubiquitous kinase

Alias namesinhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

COVID-19

Neurodegenerative Diseases

Autoimmune disorder of central nervous system

Diabetes Mellitus, Type 2

Anorexia Nervosa

Attention Deficit Disorder with Hyperactivity

Genetic Diseases, Inborn

Psoriasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

I kappa B kinase familyIKK complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.