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COMP

Gene

cartilage oligomeric matrix protein

HGNCHGNC:2227EnsemblENSG00000105664NCBI Gene1311
Locus: gene with protein productLocation: 19p13.11

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPSACH · EDM1 · EPD1 · MED · THBS5 · TSP5 · TSP-5
View full nomenclature history (10)
Previous symbolsPSACH, EDM1, EPD1
Alias symbolsMED, THBS5, TSP5, TSP-5
Previous namescartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
Alias namesthrombospondin-5, multiple epiphyseal dysplasia

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carpal Tunnel Syndrome
Neurodegenerative Diseases
Alzheimer's Disease
Parkinson's Disease
Lysosomal Storage Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Thrombospondin family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-21.
Open TargetsGene–disease associations from the Open Targets Platform.