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DEFA1B

Gene

defensin alpha 1B

HGNCHGNC:33596EnsemblENSG00000240247NCBI Gene728358
Locus: gene with protein productLocation: 8p23.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (1)
Previous namesdefensin, alpha 1B

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Glomerulonephritis, IGA
Coronary Artery Disease
Hyperlipidemias
Zika Virus Infection
COVID-19
Influenza, Human
Benign prostatic hyperplasia
Cystic Fibrosis
Scleroderma, Systemic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Defensins, alphaProteins encoded by multiple genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.