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DOT1L

Gene

DOT1 like histone lysine methyltransferase

HGNCHGNC:24948EnsemblENSG00000104885NCBI Gene84444
Locus: gene with protein productLocation: 19p13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA1814 · DOT1 · KMT4
View full nomenclature history (5)
Alias symbolsKIAA1814, DOT1, KMT4
Previous namesDOT1-like, histone H3 methyltransferase (S. cerevisiae)
Alias nameshistone methyltransferase DOT1L

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Atrial Fibrillation
Neuroblastoma
Neurodegenerative Diseases
Atrial Flutter
Osteoarthritis, Knee
Arrhythmias, Cardiac

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Histone lysine methyltransferases7BS protein lysine methyltransferases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-11-07.
Open TargetsGene–disease associations from the Open Targets Platform.