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EGLN3

Gene

egl-9 family hypoxia inducible factor 3

HGNCHGNC:14661EnsemblENSG00000129521NCBI Gene112399
Locus: gene with protein productLocation: 14q13.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Prolyl hydroxylase EGLN3Q9H6Z9

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPHD3 · HIFPH3
View full nomenclature history (4)
Alias symbolsPHD3, HIFPH3
Previous namesegl nine homolog 3 (C. elegans)
Alias namesHIF prolyl hydroxylase 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Anemia
Kidney Failure, Chronic
Eye Diseases
Glaucoma, Open-Angle
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Egl-9 family hypoxia inducible factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-10.
Open TargetsGene–disease associations from the Open Targets Platform.