FOLH1

Gene

folate hydrolase 1

HGNCHGNC:3788 EnsemblENSG00000086205 NCBI Gene2346

Locus: gene with protein productLocation: 11p11.12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Glutamate carboxypeptidase 2Q04609

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFOLH · PSM · PSMA · NAALAD1 · NAALAdase · GCP2 · GCPII

View full nomenclature history (10)

Previous symbolsFOLH

Alias symbolsPSM, PSMA, NAALAD1, NAALAdase, GCP2, GCPII

Previous namesfolate hydrolase (prostate-specific membrane antigen) 1

Alias namesglutamate carboxylase II, glutamate carboxypeptidase 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Prostatic Neoplasms

Venous Thromboembolism

Retinal Diseases

Diabetes Mellitus, Type 2

Carcinoma, Renal Cell

Pulmonary Embolism

Pulmonary Heart Disease

Neuroendocrine Tumors

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

M28 metallopeptidases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.