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GZMB

Gene

granzyme B

HGNCHGNC:4709EnsemblENSG00000100453NCBI Gene3002
Locus: gene with protein productLocation: 14q12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCTLA1 · CSPB · CCPI · CGL-1 · CSP-B · CGL1 · CTSGL1 · HLP · SECT
View full nomenclature history (16)
Previous symbolsCTLA1, CSPB
Alias symbolsCCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT
Previous namesgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Alias namesfragmentin-2, cytotoxic serine protease B, cathepsin G-like 1, T-cell serine protease 1-3E, granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Vitiligo
Respiratory Insufficiency
Alcohol drinking
Neoplasms
Arthritis, Rheumatoid
Lupus Erythematosus, Systemic
Diabetes Mellitus

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Granule associated serine proteases of immune defence

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-09-11.
Open TargetsGene–disease associations from the Open Targets Platform.