HEY1

Gene

hes related family bHLH transcription factor with YRPW motif 1

HGNCHGNC:4880 EnsemblENSG00000164683 NCBI Gene23462

Locus: gene with protein productLocation: 8q21.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHESR-1 · CHF2 · HESR1 · HRT-1 · CHF-2 · HERP2 · bHLHb31

View full nomenclature history (9)

Alias symbolsHESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, bHLHb31

Previous nameshairy/enhancer-of-split related with YRPW motif 1, hes-related family bHLH transcription factor with YRPW motif 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Carcinoma, Hepatocellular

Squamous Cell Carcinoma of Head and Neck

Osteosarcoma

Adenocarcinoma of Lung

Ovarian dysfunction

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteinsHey bHLH transcription factor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.