HMGB1

Gene

high mobility group box 1

HGNCHGNC:4983 EnsemblENSG00000189403 NCBI Gene3146

Locus: gene with protein productLocation: 13q12.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

High mobility group protein B1P09429

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHMG1 · HMG3 · SBP-1 · DKFZp686A04236

View full nomenclature history (9)

Previous symbolsHMG1

Alias symbolsHMG3, SBP-1, DKFZp686A04236

Previous nameshigh-mobility group (nonhistone chromosomal) protein 1, high-mobility group box 1

Alias namesSulfoglucuronyl carbohydrate binding protein, Amphoterin, high mobility group protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodevelopmental Disorders

Alopecia

Diabetes Mellitus, Type 2

Microcephaly

Smoking initiation

Immunologic Deficiency Syndromes

Neurodegenerative Diseases

Metabolic Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Canonical high mobility group

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.