IL10RB

Gene

interleukin 10 receptor subunit beta

HGNCHGNC:5965 EnsemblENSG00000243646 NCBI Gene3588

Locus: gene with protein productLocation: 21q22.11

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interleukin-10 receptor subunit betaQ08334

Protein · therapeutic target

Clinical-stage target · 3 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCRFB4 · D21S58 · D21S66 · CRF2-4 · CDW210B · IL-10R2

View full nomenclature history (7)

Previous symbolsCRFB4, D21S58, D21S66

Alias symbolsCRF2-4, CDW210B, IL-10R2

Previous namesinterleukin 10 receptor, beta

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

COVID-19

Inflammatory Bowel Diseases

Colitis, Ulcerative

Hepatitis C, Chronic

Carcinoma, Pancreatic Ductal

Pancreatic adenocarcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesInterleukin receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.