IL12B

Gene

interleukin 12B

HGNCHGNC:5970 EnsemblENSG00000113302 NCBI Gene3593

Locus: gene with protein productLocation: 5q33.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interleukin-12 subunit betaP29460

Protein · therapeutic target

Clinically validated target · 6 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNKSF2 · NKSF · CLMF · IL-12B · CLMF2

View full nomenclature history (12)

Previous symbolsNKSF2

Alias symbolsNKSF, CLMF, IL-12B, CLMF2

Previous namesinterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

Alias namesnatural killer cell stimulatory factor-2, cytotoxic lymphocyte maturation factor 2, p40, interleukin 12, p40, natural killer cell stimulatory factor, 40 kD subunit, interleukin-12 beta chain, IL12, subunit p40

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Inflammatory Bowel Diseases

Immune System Diseases

Skin Diseases

Dermatitis, Seborrheic

Erythematosquamous dermatosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Immunoglobulin like domain containingInterleukins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.