IL18

Gene

interleukin 18

HGNCHGNC:5986 EnsemblENSG00000150782 NCBI Gene3606

Locus: gene with protein productLocation: 11q23.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interleukin-18Q14116

Protein · therapeutic target

Clinical-stage target · 3 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIL1F4 · IGIF · IL-1g · IL-18

View full nomenclature history (6)

Alias symbolsIL1F4, IGIF, IL-1g, IL-18

Previous namesinterleukin 18 (interferon-gamma-inducing factor)

Alias namesinterferon-gamma-inducing factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphohistiocytosis, Hemophagocytic

Diabetes Mellitus, Type 2

Smoking initiation

Lupus Erythematosus, Systemic

Arthritis, Rheumatoid

Pulmonary Disease, Chronic Obstructive

Neoplasms

Acute Kidney Injury

Infections

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Interleukins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.