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JAM2

Gene

junctional adhesion molecule 2

HGNCHGNC:14686EnsemblENSG00000154721NCBI Gene58494
Locus: gene with protein productLocation: 21q21.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC21orf43 · VE-JAM · JAM-B · JAMB · CD322 · JAM-2
View full nomenclature history (8)
Previous symbolsC21orf43
Alias symbolsVE-JAM, JAM-B, JAMB, CD322, JAM-2
Alias namesvascular endothelial junction-associated molecule, junctional adhesion molecule B

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Bilateral striopallidodentate calcinosis
Ovarian dysfunction
Respiratory Tract Infections
Genetic Diseases, Inborn
Osteoarthritis, Knee
Hypothyroidism

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containingI-set domain containingIg-like cell adhesion molecule family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.