KCNH2

Gene

potassium voltage-gated channel subfamily H member 2

HGNCHGNC:6251 EnsemblENSG00000055118 NCBI Gene3757

Locus: gene with protein productLocation: 7q36.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Voltage-gated inwardly rectifying potassium channel KCNH2Q12809

Protein · therapeutic target

Clinically validated target · 14 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLQT2 · HERG · Kv11.1 · erg1

View full nomenclature history (7)

Previous symbolsLQT2

Alias symbolsHERG, Kv11.1, erg1

Previous namespotassium voltage-gated channel, subfamily H (eag-related), member 2

Alias nameshuman ether-a-go-go-related gene, long QT syndrome type 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Atrial Fibrillation

Arrhythmias, Cardiac

Ventricular Fibrillation

Tachycardia, Ventricular

Atrial Flutter

Multiple Sclerosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Potassium voltage-gated channelsPAS domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-05-07.

Open TargetsGene–disease associations from the Open Targets Platform.