KCNK10

Gene

potassium two pore domain channel subfamily K member 10

HGNCHGNC:6273 EnsemblENSG00000100433 NCBI Gene54207

Locus: gene with protein productLocation: 14q31.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Potassium channel subfamily K member 10P57789

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asK2p10.1 · TREK-2 · TREK2 · PPP1R97

View full nomenclature history (7)

Alias symbolsK2p10.1, TREK-2, TREK2, PPP1R97

Previous namespotassium channel, subfamily K, member 10, potassium channel, two pore domain subfamily K, member 10

Alias namesprotein phosphatase 1, regulatory subunit 97

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Respiratory Distress Syndrome

Cardiomyopathy, Hypertrophic

Alcohol drinking

Phobic Disorders

Joint Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Potassium two pore domain channel subfamily KProtein phosphatase 1 regulatory subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.