LOXHD1

Gene

lipoxygenase homology PLAT domains 1

HGNCHGNC:26521 EnsemblENSG00000167210 NCBI Gene125336

Locus: gene with protein productLocation: 18q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDFNB77 · FLJ32670 · LH2D1

View full nomenclature history (5)

Previous symbolsDFNB77

Alias symbolsFLJ32670, LH2D1

Previous nameslipoxygenase homology domains 1, deafness, autosomal recessive 77

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hearing loss, autosomal recessive

Nonsyndromic genetic hearing loss

Deafness

Genetic Diseases, Inborn

Non-syndromic genetic deafness

Neurodegenerative Diseases

Presbycusis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.